Income Taxes (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Current
Federal		$ 544	$ 624	$ 630
State		78	42
Deferred
Federal		(39,898)
State		(1,576)
Income tax (benefit)/expense		(40,852)	666	630
Reconciliation of the expected income tax benefit computed using the federal statutory income tax rate to the Company's effective income tax rate
Income tax expense/(benefit) computed at U.S Federal statutory tax rate		17,629	5,114	(3,603)
Permanent items		715	601	610
State income taxes		(1,523)	42	(245)
Change in valuation allowance		(56,019)	(4,705)	4,413
Uncertain income tax position		143	533	(329)
Research and development credits		(1,902)	(979)	(535)
Other		105	60	(125)
Deferred rate change				444
Income tax (benefit)/expense		(40,852)	666	630
Research and development credit carryforwards		7,100
Available NOL's		48,100
Research and development credit carryforward available in 2020 to 2021		7,100
Federal income taxes paid			0	0	$ 0
Accrued penalties related to uncertain tax positions		100
Deferred tax assets:
Net operating loss carryforward		24,926	34,610
Deferred rent credit		417	532
Accrued compensation and non-qualified stock options		8,128	5,886
Deferred financing costs		128	187
Depreciation and amortization		706	290
Research and development credits		7,119	5,529
Capitalized overhead into inventory (UNICAP 263A)		1,086	543
Nonrecourse liability related to sale of future royalties		11,223	11,526
Other		878	498
AMT credit		1,581	1,108
Valuation allowance			(60,090)
Net deferred tax asset		56,192	619
Deferred tax liability:
Debt discount on convertible notes		(141)	(509)
Infringement legal cost		(13,899)
Depreciation		(423)	(110)
Net deferred taxes		41,729
Net change in total valuation allowance	$ 60,100
Reconciliation of the beginning and ending amount of gross unrecognized tax benefits
Balance at the beginning of the period		9,341	8,964	9,828
Gross increases related to prior-year tax positions				18
Gross decreases related to prior-year tax positions		(375)	(5)
Gross increases related to current-year tax positions		662	646	710
Gross decreases related to current-year tax positions		(169)	(243)	(1,057)
Change in tax rates		(160)	(21)	(535)
Balance at the end of the period		9,299	9,341	8,964	$ 9,828
Income tax (benefit) expense		(40,852)	$ 666	$ 630
U.S. Federal
Reconciliation of the expected income tax benefit computed using the federal statutory income tax rate to the Company's effective income tax rate
NOL carryforwards		87,300
NOL carryforwards after tax effect		30,500
Available from 2015 to 2019		87,300
State
Reconciliation of the expected income tax benefit computed using the federal statutory income tax rate to the Company's effective income tax rate
NOL carryforwards		28,200
NOL carryforwards after tax effect		1,600
Minimum | U.S. Federal
Reconciliation of the expected income tax benefit computed using the federal statutory income tax rate to the Company's effective income tax rate
Available NOL's utilized per year in future years		7,100
Maximum | U.S. Federal
Reconciliation of the expected income tax benefit computed using the federal statutory income tax rate to the Company's effective income tax rate
Available NOL's utilized per year in future years		$ 20,300