Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Accrued Expenses
Accrued compensation	$ 9,145	$ 7,519
Accrued professional fees	5,919	10,057
Accrued clinical trial and clinical supply costs	4,350	3,677
Accrued product costs	1,035	113
Accrued sales and marketing expenses	528	434
Accrued interest expense	61	295
Other accrued expenses	6,396	3,058
Total	$ 27,434	$ 25,153