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Collaboration Agreements (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
Collaboration Agreements (Details) - USD ($) $ in Thousands	Sep. 30, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Collaboration agreement
Milestone revenue generated		$ 800	$ 2,000	$ 0
Revenue From Royalty Agreement	$ 30,000		30,000
Collaborative Arrangement \| United Therapeutics
Collaboration agreement
Milestone revenue generated			$ 2,000
Revenue From Royalty Agreement		$ 30,000