Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Accrued Expenses
Accrued compensation	$ 7,519	$ 5,784
Accrued professional fees	10,057	2,049
Accrued clinical trial and clinical supply costs	3,677	2,942
Accrued sales and marketing expenses	434	1,017
Accrued product costs	113	3,014
Accrued interest expense	295	639
Other accrued expenses	2,718	1,581
Total	$ 24,813	$ 17,026