Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue
Net product sales	$ 143,526	$ 89,571	$ 11,552
Revenue from royalty agreement		30,000
Licensing revenue	901	2,474	467
Total revenue	144,427	122,045	12,019
Costs and expenses
Cost of product sales	8,423	5,758	1,104
Research and development	29,135	19,586	17,245
Selling, general and administrative	89,204	72,471	55,590
Total costs and expenses	126,762	97,815	73,939
Operating income (loss)	17,665	24,230	(61,920)
Other income (expense)
Interest income	643	348	299
Interest expense	(1,229)	(4,963)	(7,849)
Changes in fair value of derivative liabilities	193	2,809	(13,354)
Loss on extinguishment of debt	(2,338)	(2,592)	(9,550)
Other income	38	39	101
Total other expense	(2,693)	(4,359)	(30,353)
Earnings (loss) before income taxes	14,972	19,871	(92,273)
Income tax expense	956
Net income (loss)	$ 14,016	$ 19,871	$ (92,273)
Income (loss) per common share:
Basic (in dollars per share)	$ 0.30	$ 0.47	$ (2.90)
Diluted (in dollars per share)	$ 0.28	$ 0.32	$ (2.90)
Weighted-average number of common shares outstanding:
Basic (in shares)	47,485,258	42,260,896	31,848,299
Diluted (in shares)	51,160,380	50,583,511	31,848,299