Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Cash flows from operating activities
Net (loss) income	$ (92,273)	$ (46,284)	$ 53,815
Income from discontinued operations			(77,040)
Loss from continuing operations	(92,273)	(46,284)	(23,225)
Adjustments to reconcile (loss) income from continuing operations to net cash used in operating activities:
Loss on extinguishment of debt	9,550
Gain on sale of property and equipment			(25)
Change in fair value of derivative liability	13,354	710	85
Unrealized gain (loss) on marketable securities	57	(57)	1
Depreciation and amortization	742	871	879
Income tax benefit	0	0	(16,245)
Amortization of deferred financing costs and debt discount	3,033	330	218
Share-based compensation expense	1,913	443	(82)
Changes in operating assets and liabilities :
Accounts receivable	(5,043)	(11)	44
Interest receivable	181	(664)	114
Inventory	(6,000)	(1,152)
Prepaid expenses and other assets	(1,070)	(516)	(247)
Accounts payable and accrued expenses	8,492	(1,098)	(959)
Deferred product revenue, net	7,883
Deferred licensing revenue	803	120	697
Other non-current liabilities	429	109	539
Net cash used in operating activities from continuing operations	(57,949)	(47,199)	(38,206)
Net cash provided by operating activities from discontinued operations			2,021
Net cash used in operating activities	(57,949)	(47,199)	(36,185)
Cash flows from investing activities
Purchases of marketable securities	(85,567)	(97,674)	(17,890)
Sales and maturities of marketable securities	75,806	49,468	26,870
Purchases of property and equipment, net	(1,646)	(753)	(685)
Capitalized patent defense costs	(705)
Net cash (used in) provided by investing activities from continuing operations	(12,112)	(48,959)	8,295
Net cash provided by disposal/sale of discontinued operations			25,607
Net cash (used in) provided by investing activities	(12,112)	(48,959)	33,902
Cash flows from financing activities
Proceeds from issuance of common stock	2,437	100,735	29
Proceeds from issuance of secured notes payable			30,000
Proceeds from convertible debt issuance	90,000
Repayment of secured notes payable	(24,344)	(6,775)
Cash settlement of debt to equity conversion	(1,727)
Financing costs and underwriters discounts	(3,627)	(6,044)	(975)
Net cash provided by financing activities from continuing operations	62,739	87,916	29,054
Net cash used in financing activities from discontinued operations			(1,967)
Net cash provided by financing activities	62,739	87,916	27,087
Net change in cash and cash equivalents	(7,322)	(8,242)	24,804
Cash and cash equivalents at beginning of year	40,302	48,544	23,740
Cash and cash equivalents at end of year	32,980	40,302	48,544
Supplemental cash flow information:
Cash paid for interest- Continuing operations	4,313	2,938	1,412
Noncash financial activity:
Conversion of convertible notes	42,417
Conversion of preferred stock		49
Issuance of warrants			612
Exercise of warrants		$ 1,156