Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Cash flows from operating activities
Net loss	$ (323,916)	$ (514,706)	$ (126,820)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	24,896	33,112	31,145
Loss on abandonment and disposals of assets, net	3,071	20,928	3,124
Impairment loss	120,489	60,504	16,773
Reacquisition of in-process research and development	0	236,748	0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net	(7,833)	30,200	(2,586)
Noncash dividend income	(48)	(14,841)	(16,756)
Amortization of premiums (discounts) on investments, net	(1,005)	(771)	411
Equity in net loss of affiliates	6,730	11,608	14,283
Stock-based compensation expense	18,950	36,296	41,576
Shares issued as payment for services	10,446	10,695	11,118
Provision for bad debts	3,242	1,779	1,217
Accretion of debt discount and amortization of deferred financing costs	9,459	4,378	0
Deferred income taxes	(3,674)	(21,278)	(2,528)
Other noncash items	837	1,093	(517)
Receivables:
Trade	(262)	(2,698)	740
Related parties	967	11,003	631
Other	(656)	(542)	661
Inventory	4,100	(478)	663
Prepaid expenses and other	(2,262)	1,006	492
Other assets	333	652	(1,017)
Accounts payable	(5,349)	4,680	(3,402)
Accrued compensation and benefits	5,186	4,385	(1,466)
Other accrued liabilities	(5,516)	356	3,007
Deferred revenue	7,423	(38,578)	(75,337)
Deferred consideration	0	0	(313)
Lease liabilities	(995)
Related party payables	45	(52)	(147)
Other long-term liabilities	(585)	281	1,328
Net cash used in operating activities	(135,927)	(124,240)	(103,720)
Cash flows from investing activities
Purchases of investments	(55,073)	(178,681)	0
Sales and maturities of investments	166,495	65,975	174,542
Purchases of preferred stock and warrants	0	0	(1,161)
Proceeds from sales of equity securities	23,456	217	235
Acquisitions of businesses, net of cash received	0	(920)	2,054
Investments in affiliates	(3,713)	(16,582)	(11,189)
Decrease in cash from deconsolidation of subsidiary	(7,244)	0	0
Return of investment in affiliate	125	2,598	0
Cash received (paid) in asset acquisitions	0	15,500	(14,219)
Purchases of property, plant and equipment	(37,883)	(41,587)	(46,666)
Proceeds from sale of assets	688	2,267	1,636
Issuances of notes receivable	0	0	(2,400)
Proceeds from repayment of notes receivable	0	0	1,500
Net cash provided by (used in) investing activities	86,851	(151,213)	104,332
Cash flows from financing activities
Proceeds from issuance of shares in a private placement	0	0	13,686
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs	6,611	87,990	0
Acquisitions of noncontrolling interests	0	0	(913)
Advances from lines of credit	11,757	4,561	5,906
Repayments of advances from lines of credit	(10,301)	(4,328)	(6,493)
Proceeds from long-term debt, net of issuance costs	376	219,859	325
Payments of long-term debt	(618)	(623)	(519)
Payments of deferred consideration for acquisitions	0	0	(8,678)
Proceeds from stock option and warrant exercises	313	2,336	980
Payment of stock issuance costs	0	0	(10)
Net cash provided by financing activities	8,138	309,795	4,284
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	(810)	295	1,055
Net increase (decrease) in cash, cash equivalents, and restricted cash	(41,748)	34,637	5,951
Cash, cash equivalents, and restricted cash
Beginning of year	110,182	75,545	69,594
End of year	68,434	110,182	75,545
Supplemental disclosure of cash flow information
Cash paid during the period for interest	3,751	3,868	617
Cash paid during the period for income taxes	50	216	566
Significant noncash activities
Stock received as consideration for collaboration agreements	4,530	0	0
Receivables converted to preferred stock	0	0	3,385
Stock and warrants issued in business combinations	0	0	16,997
Stock issued to acquire noncontrolling interests	0	0	5,082
Stock issued for reacquired in-process research and development	0	159,323	0
Long-term debt issued to a related party in an asset acquisition	0	30,000	0
Noncash dividend to shareholders	0	0	22,385
Purchases of property and equipment included in accounts payable and other accrued liabilities	694	2,267	2,257
Purchases of equipment financed through debt	0	234	0
Receivable recorded in anticipation of dissolution of affiliate	$ 0	$ 0	$ 2,598