Segments - Reconciliation of Net Loss Before Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	$ (92,835)	$ (91,479)	$ (40,644)
Other expenses:
Depreciation and amortization	(24,896)	(33,112)	(31,145)
Impairment loss	(120,489)	(60,504)	(16,773)
Stock-based compensation expense	(18,950)	(36,296)	(41,576)
Equity in net loss of affiliates	(6,730)	(11,608)	(14,283)
Other	(837)	(1,093)	517
Loss from continuing operations before income taxes	(208,687)	(429,742)	(78,367)
Operating segments
Segment Reporting Information [Line Items]
Remove cash paid for capital expenditures and investments in affiliates	15,339	19,906	31,701
Corporate And Reconciling Items
Other expenses:
Interest expense	(17,666)	(8,473)	(584)
Depreciation and amortization	(19,789)	(24,105)	(21,609)
Impairment loss	(30,810)	0	(13,823)
Reacquisition of in-process research and development	0	(236,748)	0
Stock-based compensation expense	(16,443)	(32,424)	(36,893)
Equity in net loss of affiliates	(2,416)	(8,986)	(12,436)
Other	67	0	0
Unallocated corporate costs
Other expenses:
Loss from continuing operations before income taxes	(47,577)	(84,536)	(53,197)
Eliminations
Other expenses:
Loss from continuing operations before income taxes	(14,400)	(2,343)	579
Reportable segments
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	(86,883)	(80,771)	(39,542)
All Other
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	(5,952)	(10,708)	(1,102)
Upfront and Milestone Payments | Operating segments
Segment Reporting Information [Line Items]
Add recognition of previously deferred revenue associated with upfront and milestone payments	$ 17,843	$ 39,446	$ 68,539