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Segments - Information by Reportable Segment (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Goodwill                      
Goodwill $ 63,754       $ 93,627       $ 63,754 $ 93,627 $ 93,751
Impairments   $ (178)             (29,820) 0  
Foreign currency translation adjustments                 (53) (124)  
Revenues from external customers                 90,722 151,178 219,463
Revenues 17,002 [1] $ 18,299 $ 32,836 $ 22,585 41,192 [2] $ 30,055 $ 42,771 $ 37,160      
Segment Adjusted EBITDA                 (92,835) (91,479) (40,644)
PGEN Therapeutics                      
Goodwill                      
Segment Adjusted EBITDA                 (30,166) (32,841) (5,655)
ActoBio                      
Goodwill                      
Segment Adjusted EBITDA                 (13,662) (12,797) (2,656)
MBP Titan                      
Goodwill                      
Segment Adjusted EBITDA                 (36,718) (29,403) (32,251)
Trans Ova                      
Goodwill                      
Impairments                 (29,642)    
Segment Adjusted EBITDA                 (6,337) (5,730) 1,020
All Other                      
Goodwill                      
Segment Adjusted EBITDA                 (5,952) (10,708) (1,102)
Operating segments                      
Goodwill                      
Goodwill 63,754       93,627       63,754 93,627 93,751
Reallocations from changes to reporting units                 0 0  
Impairments                 (29,820)    
Foreign currency translation adjustments                 (53) (124)  
Revenues from external customers                 90,575 151,023 219,406
Revenues                 105,141 153,302 221,462
Operating segments | PGEN Therapeutics                      
Goodwill                      
Goodwill 15,232       15,232       15,232 15,232 0
Reallocations from changes to reporting units                 0 15,232  
Impairments                 0    
Foreign currency translation adjustments                 0 0  
Revenues from external customers                 2,227 29,021 53,184
Revenues                 13,568 29,638 53,184
Operating segments | ActoBio                      
Goodwill                      
Goodwill 1,735       1,788       1,735 1,788 0
Reallocations from changes to reporting units                 0 1,788  
Impairments                 0    
Foreign currency translation adjustments                 (53) 0  
Revenues from external customers                 (364) 6,684 12,929
Revenues                 134 7,524 14,112
Operating segments | MBP Titan                      
Goodwill                      
Goodwill 9,635       0       9,635 0 0
Reallocations from changes to reporting units                 9,635 0  
Impairments                 0    
Foreign currency translation adjustments                 0 0  
Revenues from external customers                 3,813 9,927 14,336
Revenues                 3,909 9,936 14,336
Operating segments | Trans Ova                      
Goodwill                      
Goodwill 16,594       46,236       16,594 46,236 46,236
Reallocations from changes to reporting units                 0 0  
Impairments                 (29,642)    
Foreign currency translation adjustments                 0 0  
Revenues from external customers                 68,672 75,178 79,783
Revenues                 70,033 75,736 80,026
Operating segments | All Other                      
Goodwill                      
Goodwill $ 20,558       $ 30,371       20,558 30,371 47,515
Reallocations from changes to reporting units                 (9,635) (17,020)  
Impairments                 (178)    
Foreign currency translation adjustments                 0 (124)  
Revenues from external customers                 16,227 30,213 59,174
Revenues                 17,497 30,468 59,804
Intersegment revenues                      
Goodwill                      
Revenues                 14,566 2,279 2,056
Intersegment revenues | PGEN Therapeutics                      
Goodwill                      
Revenues                 11,341 617 0
Intersegment revenues | ActoBio                      
Goodwill                      
Revenues                 498 840 1,183
Intersegment revenues | MBP Titan                      
Goodwill                      
Revenues                 96 9 0
Intersegment revenues | Trans Ova                      
Goodwill                      
Revenues                 1,361 558 243
Intersegment revenues | All Other                      
Goodwill                      
Revenues                 $ 1,270 $ 255 $ 630
[1]
During the fourth quarter of 2019, the Company recorded a goodwill impairment charge related to the Trans Ova reporting unit (Note 11) as well as impairment charges on certain assets held for sale (Note 3).
[2]
During the fourth quarter of 2018, the Company reacquired certain in-process research and development from ZIOPHARM, Ares Trading, and Intrexon T1D Partners, all of which were immediately expensed (Notes 5 and 6). The Company also recorded a loss on abandonment of certain of its intangible assets (Note 11). The Company also recognized the remaining balance of deferred revenue associated with Histogenics and Synthetic Biologics upon the mutual termination of the ECCs with these entities (Note 18).