Related Party Transactions - Additional Information (Details) - USD ($)	1 Months Ended							10 Months Ended	12 Months Ended
	Jan. 31, 2020	Dec. 31, 2019	Jan. 31, 2018	Dec. 31, 2017	Mar. 31, 2017	Jun. 30, 2016	Nov. 30, 2015	Jul. 31, 2018	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017	Oct. 31, 2017
Related Party Transaction [Line Items]
Shares issued as payment for services									$ 10,446,000	$ 10,695,000	$ 11,118,000
Shares issued during the period (in shares)			6,900,000	1,207,980
Dividend income from investments in preferred stock									48,000	14,841,000	16,756,000
Purchase of preferred stock									0	0	1,161,000
Equity securities										1,024,000
Revenues									90,722,000	151,178,000	219,463,000
Purchases of property and equipment									37,883,000	41,587,000	46,666,000
Third Security
Related Party Transaction [Line Items]
Services agreement, term							1 year
Expense for services									$ 26,000	$ 47,000	$ 409,000
Shares issued as payment for services, shares									1,606,062	696,033	500,650
Shares issued as payment for services									$ 8,233,000	$ 8,324,000	$ 8,704,000
Sublease rental income									89,000
Sublease rental income										89,000	43,000
Affiliates of Third Security
Related Party Transaction [Line Items]
Shares issued during the period (in shares)			1,000,000
Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Equity securities										640,000
Business acquisition, equity interest issued or issuable, value assigned		$ 1,280,000
Fair value, option, changes in fair value, gain (loss)									$ 3,222,000
Intrexon Energy Partners, LLC
Related Party Transaction [Line Items]
Purchases of property and equipment				$ 2,812,000
Harvest Intrexon Enterprise Fund I, LP
Related Party Transaction [Line Items]
Other nonoperating income											1,839,000
Common Stock | Third Security
Related Party Transaction [Line Items]
Expense for services							$ 800,000
Series A Preferred Shares
Related Party Transaction [Line Items]
Shares issued during the period (in shares)								0
Series A Preferred Shares | Affiliates of Third Security
Related Party Transaction [Line Items]
Convertible preferred stock, amount authorized												$ 100,000,000
ZIOPHARM Oncology, Inc.
Related Party Transaction [Line Items]
Dividend income from investments in preferred stock										14,793,000	16,717,000
Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Purchase of preferred stock					$ 1,161,000
Other assets | Convertible note and warrants | Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Equity securities										120,000
Third Security | Chief Executive Officer
Related Party Transaction [Line Items]
Ownership interest		100.00%							100.00%
ZIOPHARM Oncology, Inc.
Related Party Transaction [Line Items]
Preferred shares, stated value (in usd per share)						$ 1,200
Preferred shares, dividend rate (in usd per share)						$ 12.00
Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Convertible preferred shares, shares issued					1,161
Number of common shares into which warrants are convertible (in shares)					99,769
Preferred stock, dividend rate, percentage					4.00%
Collaboration and licensing agreements
Related Party Transaction [Line Items]
Revenues									$ 14,059,000	69,540,000	134,624,000
Collaboration and licensing agreements | Histogenics Corporation, OvaScience Inc., and Synthetic Biologics Inc.
Related Party Transaction [Line Items]
Revenues									11,877,000
Preferred stock | Other assets | Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Equity securities										191,000
ZIOPHARM Oncology, Inc.
Related Party Transaction [Line Items]
Collaborative arrangement consideration received, number of preferred shares (in shares)						100,000
ZIOPHARM Oncology, Inc. | Collaboration and licensing agreements
Related Party Transaction [Line Items]
Collaborative arrangement consideration received, number of preferred shares (in shares)						100,000
Revenues									$ 2,171,000	$ 16,298,000	$ 69,812,000
Subsequent Event | Fibrocell Science, Inc.
Related Party Transaction [Line Items]
Business acquisition, equity interest issued or issuable, value assigned	$ 3,311,000