Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Federal and state research and development tax credits	$ 12,160	$ 11,168
Accumulated deficit	1,868,567	$ 1,915,556
Foreign Subsidiaries
Operating Loss Carryforwards [Line Items]
Accumulated deficit	26,184
Domestic
Operating Loss Carryforwards [Line Items]
Net operating losses inherited via acquisition	41,400
Operating loss carryforwards	819,100
Deferred tax assets, capital loss carryforwards	212,500
Federal and state research and development tax credits	12,100
Foreign
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	71,000
Generated after 2017 | Domestic
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	$ 604,200