Share-Based Payments (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Stock-based Compensation Expense

Stock-based compensation costs included in the consolidated statements of operations are presented below:

	Year Ended December 31,
	2022		2021		2020
Cost of products and services	$	110	$	161	$	66
Research and development	2,188		2,706		611
Selling, general and administrative	7,899		10,687		18,331
Discontinued operations	9		350		(642)
Total	$	10,206	$	13,904	$	18,366

Schedule of Stock Option Activity

Stock option activity was as follows:

	Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2019	9,022,282	$	21.94	6.10
Granted	5,693,498	10.03
Exercised	(30,061)	(3.88)
Forfeited	(976,324)	(15.47)
Expired	(2,453,499)	26.53
Balances at December 31, 2020	11,255,896	15.53		7.25
Granted	2,058,820	7.59
Exercised	(127,883)	(4.75)
Forfeited	(305,293)	(7.02)
Expired	(621,353)	(24.61)
Balances at December 31, 2021	12,260,187	14.06		6.79
Granted	4,451,890	2.22
Exercised	(375)	(2.28)
Forfeited	(567,179)	(5.19)
Expired	(943,247)	(22.32)
Balances at December 31, 2022	15,201,276	10.41		6.87
Exercisable at December 31, 2022	8,559,359	13.58		5.75

Summary of Information About Stock Options Outstanding

The following table summarizes additional information about stock options outstanding as of December 31, 2022:

					Options Outstanding						Options Exercisable
Range of Exercise Prices					Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value		Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value
$	1.22	—	$	2.33	4,944,982	$	2.17	8.85	$	7,630	1,602,732	$	2.02	8.21	$	2,708
$	2.53	—	$	8.17	3,903,425	6.39		7.52	73		2,170,946	6.14		7.19	16
$	8.20	—	$	17.85	3,601,175	14.45		6.78	—		2,033,987	14.33		6.60	—
$	18.19	—	$	45.11	2,626,227	24.65		2.55	—		2,626,227	24.65		2.55	—
$	45.69				125,467	45.69		2.08	—		125,467	45.69		2.08	—
					15,201,276	$	10.41	6.87	$	7,703	8,559,359	$	13.58	5.75	$	2,724

The following table summarizes additional information about stock options outstanding as of December 31, 2021:

					Options Outstanding						Options Exercisable
Range of Exercise Prices					Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value		Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value
$	1.55	—	$	5.95	3,290,348	$	4.64	8.18	$	1,329	2,031,348	$	4.15	7.98	$	1,327
$	6.01	—	$	11.90	3,568,102	9.69		8.46	—		833,104	9.79		7.90	—
$	12.01	—	$	20.94	3,068,340	18.59		6.09	—		1,880,991	19.16		4.93	—
$	21.13	—	$	45.69	2,332,393	28.06		3.22	—		2,332,393	28.06		3.22	—
$	47.35	—	$	47.35	1,004	47.35		3.51	—		1,004	47.35		3.51	—
					12,260,187	$	14.06	6.79	$	1,329	7,078,840	$	16.69	5.59	$	1,327

Schedule of Restricted Stock Unit Activity

RSU activity was as follows:

	Number of Restricted Stock Units	Weighted Average Grant Date Fair Value		Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2019	1,781,982	$	8.71	1.24
Granted	3,157,390	3.09
Vested	(2,802,593)	(3.99)
Forfeited	(409,067)	(8.59)
Balances at December 31, 2020	1,727,712	6.11		0.42
Granted	462,019	7.87
Vested	(1,624,013)	(5.76)
Forfeited	(97,237)	(8.96)
Balances at December 31, 2021	468,481	8.47		0.33
Granted	1,387,831	2.12
Vested	(1,125,785)	4.29
Forfeited	(32,712)	7.26
Balances at December 31, 2022	697,815	2.66		0.13