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Goodwill and Intangible Assets, Net
 12 Months Ended
Dec. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]  
Goodwill and Intangible Assets, Net Goodwill and Intangible Assets, Net
The changes in the carrying amount of goodwill for the years ended December 31, 2022 and 2021, are as follows:
20222021
Beginning of year$37,554 $37,769 
Impairment(482)— 
Foreign currency translation adjustments(149)(215)
End of year$36,923 $37,554 
The Company had $14,483 and $14,001 of cumulative goodwill impairment losses as of December 31, 2022 and 2021,
The Company recorded $482 of goodwill impairment related to the total goodwill assigned to one reporting unit within the biopharmaceutical segment during the year ended December 31, 2022.
See Note 18 for information regarding goodwill by reportable segment.
Intangible assets consist of the following as of December 31, 2022: 
Weighted Average Useful Life (Years)Gross Carrying AmountAccumulated AmortizationNet
Patents, developed technologies and know-how16.4$80,892 $(36,437)$44,455 
Customer relationships3.01,600 (1,600)— 
Trademarks5.0200 (200)— 
Total$82,692 $(38,237)$44,455 
Intangible assets consist of the following as of December 31, 2021: 
Gross Carrying AmountAccumulated AmortizationNet
Patents, developed technologies and know-how$85,173 $(32,882)$52,291 
Customer relationships1,600 (1,600)— 
Trademarks200 (200)— 
Total$86,973 $(34,682)$52,291 
Amortization expense was $4,798, $5,273, and $5,243 for the years ended December 31, 2022, 2021, and 2020, respectively. Estimated aggregate amortization expense for definite lived intangible assets is expected to be as follows:
2023$4,773 
20244,773 
20254,773 
20264,773 
20274,773 
Thereafter20,590 
Total$44,455