Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash flows from operating activities
Net loss	$ (92,166)	$ (170,521)	$ (323,916)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	13,761	17,516	24,896
Loss on disposals of assets, net	150	4,442	3,071
Impairment of goodwill	0	9,635	87,862
Impairment of other noncurrent assets	543	13,326	32,627
Gain on sale of discontinued operations	0	(672)	0
Loss on release of cumulative foreign currency translation adjustment	0	26,957	0
Loss on settlement agreement	0	11,436	0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net	0	106	(7,833)
Noncash dividend income	0	0	(48)
Amortization of premiums (discounts) on investments, net	1,232	(699)	(1,005)
Equity in net loss of affiliates	3	1,176	6,730
Stock-based compensation expense	13,904	18,366	18,950
Shares issued as payment for services	577	1,006	10,446
Provision for credit losses	1,268	899	3,242
Accretion of debt discount and amortization of deferred financing costs	11,735	10,587	9,459
Deferred income taxes	(167)	(156)	(3,674)
Noncash (gain) loss on termination of leases	(5,831)	191	0
Other noncash items	24	35	837
Receivables:
Trade	(6,176)	2,214	(262)
Related parties	(54)	258	967
Other	(330)	1,853	(656)
Inventory	(1,903)	2,511	4,100
Prepaid expenses and other	520	(812)	(2,262)
Other assets	305	(142)	333
Accounts payable	420	(1,097)	(5,349)
Accrued compensation and benefits	2,853	(789)	5,186
Other accrued liabilities	1,850	(2,682)	(5,516)
Deferred revenue	1,656	(21,045)	7,423
Lease liabilities	97	(887)	(995)
Related party payables	8	(33)	45
Other long-term liabilities	(50)	0	(585)
Net cash used in operating activities	(55,771)	(77,021)	(135,927)
Cash flows from investing activities
Purchases of investments	(174,221)	(171,360)	(55,073)
Sales and maturities of investments	100,168	133,000	166,495
Proceeds from sales of equity securities	0	0	23,456
Investments in affiliates	0	0	(3,713)
Decrease in cash from deconsolidation of subsidiary	0	0	(7,244)
Return of investment in affiliate	0	0	125
Purchases of property, plant and equipment	(7,247)	(7,527)	(37,883)
Proceeds from sale of assets	3,006	6,484	688
Proceeds from sale of discontinued operations, net of cash sold	0	64,240	0
Proceeds from repayment of notes receivable	3,754	2,942	0
Net cash provided by (used in) investing activities	(74,540)	27,779	86,851
Cash flows from financing activities
Proceeds from issuance of shares and warrants, net of issuance costs	121,045	35,000	6,611
Advances from lines of credit	0	10,005	11,757
Repayments of advances from lines of credit	0	(11,927)	(10,301)
Proceeds from long-term debt, net of issuance costs	0	0	376
Payments of long-term debt	(466)	(490)	(618)
Proceeds from stock option and warrant exercises	608	117	313
Net cash provided by financing activities	121,187	32,705	8,138
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	217	353	(810)
Net decrease in cash, cash equivalents, and restricted cash	(8,907)	(16,184)	(41,748)
Cash, cash equivalents, and restricted cash
Beginning of year	52,250	68,434	110,182
End of year	43,343	52,250	68,434
Supplemental disclosure of cash flow information
Cash paid during the period for interest	7,155	7,202	3,751
Cash paid during the period for income taxes	36	48	50
Significant noncash activities
Fair value of stock received as consideration for collaboration agreements	0	0	4,530
Fair value of stock issued upon conversion of long-term debt	0	56,827	0
Fair value of stock issued in conjunction with settlement agreement	0	18,103	0
Accrued compensation paid in equity awards	0	5,100	1,102
Purchases of property and equipment included in accounts payable and other accrued liabilities	820	277	694
Proceeds from sale of assets included in receivables	$ 14	$ 4,227	$ 0