Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Operating Loss Carryforwards [Line Items]
Federal and state research and development tax credits	$ 11,168	$ 10,210
Accumulated deficit	1,915,556	$ 1,823,390
Foreign Subsidiaries
Operating Loss Carryforwards [Line Items]
Accumulated deficit	23,100
Domestic
Operating Loss Carryforwards [Line Items]
Net operating losses inherited via acquisition	42,100
Operating loss carryforwards	856,400
Deferred tax assets, capital loss carryforwards	212,500
Federal and state research and development tax credits	11,100
Foreign
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	75,700
Generated after 2017 | Domestic
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards	$ 603,700