Share-Based Payments (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Schedule of Stock-based Compensation Expense

Stock-based compensation costs included in the consolidated statements of operations are presented below:

	Year Ended December 31,
	2021		2020		2019
Cost of products	$	30	$	10	$	20
Cost of services	172		134		220
Research and development	2,735		1,815		3,478
Selling, general and administrative	10,967		17,787		11,380
Discontinued operations	—		(1,380)		3,852
Total	$	13,904	$	18,366	$	18,950

Schedule of Stock Option Activity

Stock option activity was as follows:

	Number of Shares	Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018	11,093,063	$	27.95	6.81
Granted	1,556,575	6.52
Exercised	(19,887)	(3.17)
Forfeited	(1,236,326)	(24.92)
Expired	(2,371,143)	(38.53)
Balances at December 31, 2019	9,022,282	21.94		6.10
Granted	5,693,498	10.03
Exercised	(30,061)	(3.88)
Forfeited	(976,324)	(15.47)
Expired	(2,453,499)	(26.53)
Balances at December 31, 2020	11,255,896	15.53		7.25
Granted	2,058,820	7.59
Exercised	(127,883)	(4.75)
Forfeited	(305,293)	(7.02)
Expired	(621,353)	(24.61)
Balances at December 31, 2021	12,260,187	14.06		6.79
Exercisable at December 31, 2021	7,078,840	16.69		5.59

Summary of Information About Stock Options Outstanding

The following table summarizes additional information about stock options outstanding as of December 31, 2021:

					Options Outstanding						Options Exercisable
Range of Exercise Prices					Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value		Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value
$	1.55	—	$	5.95	3,290,348	$	4.64	8.18	$	1,329	2,031,348	$	4.15	7.98	$	1,327
$	6.01	—	$	11.90	3,568,102	9.69		8.46	—		833,104	9.79		7.90	—
$	12.01	—	$	20.94	3,068,340	18.59		6.09	—		1,880,991	19.16		4.93	—
$	21.13	—	$	45.69	2,332,393	28.06		3.22	—		2,332,393	28.06		3.22	—
$	47.35				1,004	47.35		3.51	—		1,004	47.35		3.51	—
					12,260,187	$	14.06	6.79	$	1,329	7,078,840	$	16.69	5.59	$	1,327

The following table summarizes additional information about stock options outstanding as of December 31, 2020:

					Options Outstanding						Options Exercisable
Range of Exercise Prices					Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value		Number of Options	Weighted Average Exercise Price		Weighted Average Remaining Life (Years)	Aggregate Intrinsic Value
$	1.55	—	$	5.95	3,259,685	$	4.63	8.92	$	18,157	1,271,310	$	3.11	8.73	$	9,018
$	6.06	—	$	15.09	2,261,216	11.01		8.23	1,325		345,788	9.09		4.76	689
$	15.80	—	$	20.94	3,028,309	18.85		7.38	—		1,216,258	19.82		5.62	—
$	21.13	—	$	36.84	2,303,371	26.33		4.32	—		2,200,996	26.52		4.22	—
$	37.88	—	$	47.35	403,315	42.26		4.01	—		403,315	42.26		4.01	—
					11,255,896	$	15.53	7.25	$	19,482	5,437,667	$	19.61	5.61	$	9,707

Schedule of Restricted Stock Unit Activity

RSU activity was as follows:

	Number of Restricted Stock Units	Weighted Average Grant Date Fair Value		Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018	970,341	$	13.82	1.43
Granted	2,278,460	6.59
Vested	(1,159,165)	(8.74)
Forfeited	(307,654)	(8.99)
Balances at December 31, 2019	1,781,982	8.71		1.24
Granted	3,157,390	3.09
Vested	(2,802,593)	(3.99)
Forfeited	(409,067)	(8.59)
Balances at December 31, 2020	1,727,712	6.11		0.42
Granted	462,019	7.87
Vested	(1,624,013)	(5.76)
Forfeited	(97,237)	(8.96)
Balances at December 31, 2021	468,481	8.47		0.33