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Summary of Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2021
Accounting Policies [Abstract]  
Accounts Receivable, Allowance for Credit Losses
The following table shows the activity in the allowance for credit losses for the years ended December 31, 2021, 2020, and 2019:
 202120202019
Beginning balance$6,334 $7,513 $4,991 
Charged to operating expenses1,268 899 3,384 
Write offs of accounts receivable, net of recoveries(1,805)(2,078)(862)
Ending balance$5,797 $6,334 $7,513 
Estimated Useful Lives of Property, Plant and Equipment The estimated useful lives of these assets from continuing operations are as follows:
 Years
Land improvements
4–15
Buildings and building improvements
3–23
Furniture and fixtures
1–7
Equipment
1–9
Breeding stock
1–4
Computer hardware and software
1–7
Leasehold improvements are amortized over the shorter of the useful life of the asset or the applicable lease term, generally one to fourteen years.
Summary of Assumptions Used in Option Pricing Model The assumptions used in the Black-Scholes option pricing model for the years ended December 31, 2021, 2020, and 2019 are set forth in the table below:
202120202019
Valuation assumptions
Expected dividend yield0%0%0%
Expected volatility
87%–90%
59%–90%
58%–64%
Expected term (years)6.00
6.00–10.00
6.25
Risk-free interest rate
0.61%–1.33%
0.36%–1.80%
1.53%–2.58%
Potentially Dilutive Securities Excluded from Calculation of Net Loss per Share
The following potentially dilutive securities as of December 31, 2021, 2020, and 2019, have been excluded from the computations of diluted weighted average shares outstanding for the years then ended as they would have been anti-dilutive: 
 December 31,
202120202019
Convertible debt11,732,440 11,732,440 21,323,068 
Options12,260,187 11,255,896 9,022,282 
Restricted stock units468,481 1,727,712 1,781,982 
Warrants121,888 133,264 133,264 
Total24,582,996 24,849,312 32,260,596