Segments - Reconciliation of Net Loss Before Income Taxes (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA for reportable segments	$ (13,596)	$ (7,358)	$ (12,862)	$ (16,178)
Other expenses:
Depreciation and amortization			(10,442)	(13,701)
Loss on disposals of assets			(89)	(1,606)
Stock-based compensation expense	(2,490)	(4,600)	(11,462)	(13,869)
Equity in net loss of affiliates			(3)	(1,163)
Other			4,600	(108)
Loss before income taxes	(29,885)	(27,586)	(71,904)	(64,221)
Add recognition of previously deferred revenue associated with upfront and milestone payments
Segment Reporting Information [Line Items]
Add recognition of previously deferred revenue associated with upfront and milestone payments	22	5,213	380	19,654
Operating segments
Segment Reporting Information [Line Items]
Remove cash paid for capital expenditures, net of proceeds from sale of assets, and cash paid for investments in affiliates	1,962	244	3,360	3,395
Operating segments | Add recognition of previously deferred revenue associated with upfront and milestone payments
Segment Reporting Information [Line Items]
Add recognition of previously deferred revenue associated with upfront and milestone payments	1,163	7,132	1,849	25,178
Corporate And Reconciling Items
Other expenses:
Interest expense	(4,799)	(4,646)	(14,005)	(13,830)
Depreciation and amortization	(3,399)	(3,786)	(10,442)	(11,364)
Loss on disposals of assets	(318)	(615)	(553)	(1,593)
Impairment losses	0	(920)	(543)	(920)
Stock-based compensation expense	(2,490)	(4,628)	(11,462)	(15,249)
Adjustment related to accrued bonuses paid in equity awards	0	0	0	2,833
Equity in net loss of affiliates	0	(523)	(3)	(1,125)
Other	(5)	4	(19)	16
Unallocated corporate costs
Other expenses:
Loss before income taxes	(7,166)	(10,452)	(25,412)	(29,102)
Eliminations
Other expenses:
Loss before income taxes	(1,237)	(2,038)	(1,812)	(6,282)
Segment Adjusted EBITDA for reportable segments
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA for reportable segments	$ (13,596)	$ (7,358)	$ (12,862)	$ (16,178)