Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019
Cash flows from operating activities
Net loss	$ (128,860)	$ (154,701)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	13,701	18,711
Loss on disposals of assets, net	1,606	1,875
Impairment of goodwill	9,635	178
Impairment of other noncurrent assets	13,326	448
Gain on sale of discontinued operations	672	0
Loss on release of cumulative foreign currency translation adjustments to loss from discontinued operations	26,957	0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net	106	(2,634)
Amortization of discounts on investments, net	(652)	(949)
Equity in net loss of affiliates	1,163	5,034
Stock-based compensation expense	13,869	14,538
Shares issued as payment for services	1,006	7,987
Provision for credit losses	759	787
Accretion of debt discount and amortization of deferred financing costs	7,807	6,962
Deferred income taxes	(204)	(1,448)
Other noncash items	108	3,246
Receivables:
Trade	952	241
Related parties	265	1,190
Other	1,807	462
Inventory	5,411	4,775
Prepaid expenses and other	(1,777)	(4,320)
Other assets	(125)	(41)
Accounts payable	(1,556)	(4,432)
Accrued compensation and benefits	(1,605)	535
Other accrued liabilities	(3,072)	(5,651)
Deferred revenue	(20,304)	5,056
Lease liabilities	(508)	(1,087)
Related party payables	305	38
Other long-term liabilities	0	(585)
Net cash used in operating activities	(60,552)	(103,785)
Cash flows from investing activities
Purchases of investments	(171,360)	(55,073)
Sales and maturities of investments	96,000	130,496
Proceeds from sales of equity securities	0	589
Investments in affiliates	0	(3,713)
Decrease in cash from deconsolidation of subsidiary	0	(7,244)
Return of investment in affiliate	0	125
Purchases of property, plant and equipment	(6,058)	(33,199)
Proceeds from sale of assets	1,831	361
Proceeds from sale of discontinued operations, net of cash sold	64,240	0
Proceeds from repayment of notes receivable	2,942	0
Net cash provided by (used in) investing activities	(12,405)	32,342
Cash flows from financing activities
Proceeds from issuance of shares in a private placement	35,000	0
Proceeds from issuance of shares and warrants in public offering, net of issuance costs	0	6,611
Advances from lines of credit	10,005	4,623
Repayments of advances from lines of credit	(11,927)	(4,520)
Proceeds from long-term debt, net of issuance costs	0	376
Payments of long-term debt	(370)	(464)
Proceeds from stock option and warrant exercises	69	313
Net cash provided by financing activities	32,777	6,939
Effect of exchange rate changes on cash, cash equivalents, and restricted cash	(77)	(843)
Net decrease in cash, cash equivalents, and restricted cash	(40,257)	(65,347)
Cash, cash equivalents, and restricted cash
Beginning of period	68,434	110,182
End of period	28,177	44,835
Supplemental disclosure of cash flow information
Cash paid during the period for interest	7,155	3,698
Cash paid during the period for income taxes	48	50
Significant noncash activities
Stock received as consideration for collaboration agreements	0	4,530
Stock issued upon conversion of long-term debt	31,827	0
Accrued compensation paid in equity awards	5,100	1,102
Purchases of property and equipment included in accounts payable and other accrued liabilities	461	692
Sales of property and equipment included in accounts receivable, trade	435	0
Cash, cash equivalents, and restricted cash
Cash, cash equivalents, and restricted cash	$ 68,434	$ 44,835