Segments - Reconciliation of Net Loss Before Income Taxes (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	$ (33,242)	$ (32,556)	$ (102,247)	$ (93,698)
Other expenses:
Interest expense	(4,471)	(3,999)	(13,140)	(4,240)
Depreciation and amortization			(18,711)	(25,184)
Impairment loss	(626)	0	(626)	0
Stock-based compensation expense	(5,423)	(8,132)	(14,538)	(28,340)
Equity in net loss of affiliates	(1,647)	(2,870)	(5,034)	(9,880)
Other			(3,284)	(635)
Loss before income taxes	(54,146)	(73,068)	(156,316)	(192,519)
Operating segments
Segment Reporting Information [Line Items]
Remove cash paid for capital expenditures and investments in affiliates	8,115	10,373	34,021	30,422
Corporate And Reconciling Items
Other expenses:
Interest expense	(4,471)	(3,999)	(13,140)	(4,240)
Depreciation and amortization	(6,021)	(8,303)	(18,711)	(25,184)
Impairment loss	(626)	0	(626)	0
Reacquisition of in-process research and development	0	(8,721)	0	(8,721)
Stock-based compensation expense	(5,423)	(8,132)	(14,538)	(28,340)
Equity in net loss of affiliates	(1,647)	(2,870)	(5,034)	(9,880)
Other	35	0	35	0
Unallocated corporate costs
Other expenses:
Loss before income taxes	(13,544)	(25,440)	(43,657)	(75,319)
Eliminations
Other expenses:
Loss before income taxes	(3,092)	(621)	(9,104)	(1,659)
Reportable segments
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	(24,716)	(23,502)	(76,227)	(62,610)
All Other
Segment Reporting Information [Line Items]
Segment Adjusted EBITDA	(8,526)	(9,054)	(26,020)	(31,088)
Upfront and Milestone Payments | Operating segments
Segment Reporting Information [Line Items]
Add recognition of previously deferred revenue associated with upfront and milestone payments	$ 5,770	$ 7,201	$ 16,685	$ 24,100