Share-Based Payments (Tables)

9 Months Ended

Sep. 30, 2019

Share-based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Costs

Stock-based compensation costs included in the consolidated statements of operations are presented below:

	Three Months Ended   September 30,				Nine Months Ended   September 30,
	2019		2018		2019		2018
Cost of products	$	4	$	14	$	16	$	64
Cost of services	52		51		169		207
Research and development	1,838		1,681		5,565		7,315
Selling, general and administrative	3,529		6,386		8,788		20,754
Total	$	5,423	$	8,132	$	14,538	$	28,340

Schedule of Stock Option Activity

Stock option activity was as follows:

	Number of Shares		Weighted Average Exercise Price			Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018	11,093,063		$	27.95		6.81
Granted	1,536,075		6.53
Exercised	(19,887	)	(3.17		)
Forfeited	(824,192	)	(29.81		)
Expired	(2,254,576	)	(39.05		)
Balances at September 30, 2019	9,530,483		21.77			6.68
Exercisable at September 30, 2019	6,306,218		24.97			5.81

Schedule of Restricted Stock Unit Activity

RSU activity was as follows:

	Number of Restricted Stock Units		Weighted Average Grant Date Fair Value			Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018	970,341		$	13.82		1.43
Granted	2,278,460		6.59
Vested	(927,880	)	(9.25		)
Forfeited	(212,412	)	(9.20		)
Balances at September 30, 2019	2,108,509		8.48			1.33