Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Mar. 31, 2018		Dec. 31, 2017
Deferred Revenue Arrangement [Line Items]
Current portion of deferred revenue	$ 38,376	[1]	$ 42,870
Long-term portion of deferred revenue	162,318	[1]	193,527
Deferred revenue	200,694		236,397
Collaboration and licensing agreements
Deferred Revenue Arrangement [Line Items]
Deferred revenue	195,478		231,583
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,138		4,681
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 78		$ 133

[1] The current and long-term portion of deferred revenue from related parties, as previously reported, totaled $28,684 and $147,708, respectively. The effect of restatement caused decreases of $12,260 and $12,074, respectively, resulting in current and long-term deferred revenue from related parties, as restated, totaling $16,424 and $135,634, respectively.