Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Deferred Revenue Arrangement [Line Items]
Current portion of deferred revenue	$ 48,646	$ 42,870
Long-term portion of deferred revenue	214,744	193,527
Deferred revenue	263,390	236,397
Collaboration and licensing agreements
Deferred Revenue Arrangement [Line Items]
Deferred revenue	258,174	231,583
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,138	4,681
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 78	$ 133