Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Computed statutory income tax benefit	$ (44,098)	$ (66,011)	$ (29,573)
State and provincial income tax benefit, net of federal income taxes	(3,294)	(7,905)	(3,157)
Nondeductible stock based compensation	4,147	3,321	3,182
Nondeductible officer compensation	476	0	2,433
Gain on dividend distribution of AquaBounty common stock	3,965	0	0
Impairment of goodwill	4,700	0	0
Research and development tax incentives	(1,166)	(6,350)	(348)
Acquisition and internal restructuring transaction costs	354	571	883
Provisional impact of the Tax Act	85,288	0	0
Enacted changes in foreign tax rates and foreign tax reforms	2,138	0	(961)
U.S.-foreign rate differential	5,410	3,463	620
Other, net	(64)	1,485	(98)
Income tax reconciliation income tax benefit before valuation allowance, total	57,856	(71,426)	(27,019)
Change in valuation allowance for deferred tax assets	(60,736)	67,549	28,035
Total income tax expense (benefit)	$ (2,880)	$ (3,877)	$ 1,016