Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Cash flows from operating activities
Net loss	$ (126,820)	$ (190,274)	$ (87,994)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	31,145	24,572	17,743
Loss on disposal of long-lived assets	3,124	666	633
Impairment loss	16,773	0	0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock	(2,586)	58,894	(66,876)
Noncash dividend income	(16,756)	(7,421)	0
Amortization of premiums on investments	411	1,070	642
Equity in net loss of affiliates	14,283	21,120	8,944
Stock-based compensation expense	41,576	42,202	38,667
Shares issued as payment for services	11,118	10,777	2,169
Shares issued as consideration for license agreement	0	0	59,579
Provision for bad debts	1,217	1,963	1,757
Deferred income taxes	(2,528)	(3,467)	1,117
Other noncash items	(517)	1,662	460
Changes in operating assets and liabilities:
Restricted cash	0	(6,987)	0
Receivables:
Trade	740	2,588	(12,138)
Related parties	631	6,804	(11,042)
Notes	0	(42)	0
Other	661	271	5,286
Inventory	663	3,807	(774)
Prepaid expenses and other	492	(932)	(2,729)
Other assets	(1,436)	2,189	(2,119)
Accounts payable	(3,402)	3,618	(3,263)
Accrued compensation and benefits	(1,466)	(12,402)	10,491
Other accrued liabilities	3,007	9,002	1,593
Deferred revenue	(75,337)	(25,481)	74,434
Deferred consideration	(313)	(630)	(943)
Related party payables	(147)	310	(64)
Other long term liabilities	1,328	146	96
Net cash provided by (used in) operating activities	(104,139)	(55,975)	35,669
Cash flows from investing activities
Purchases of investments	0	(75,246)	(181,572)
Maturities of investments	174,542	101,987	88,000
Purchases of equity securities, preferred stock, and warrants	(1,161)	(2,308)	(17,080)
Proceeds from sales of equity securities	235	280	0
Acquisitions of businesses, net of cash received	2,054	0	(123,928)
Investments in affiliates	(11,189)	(11,542)	(13,442)
Cash paid in asset acquisition	(14,219)	(7,244)	0
Purchases of property, plant and equipment	(46,666)	(31,629)	(12,749)
Proceeds from sale of property, plant and equipment	1,636	274	626
Issuances of notes receivable	(2,400)	(2,964)	(600)
Proceeds from repayment of notes receivable	1,500	0	1,500
Net cash provided by (used in) investing activities	104,332	(28,392)	(259,245)
Cash flows from financing activities
Proceeds from issuance of shares in a private placement	13,686	0	0
Proceeds from issuance of shares in public offerings, net of issuance costs	0	0	328,234
Acquisitions of noncontrolling interests	(913)	0	(1,566)
Advances from lines of credit	5,906	5,075	15,232
Repayments of advances from lines of credit	(6,493)	(4,816)	(16,944)
Proceeds from long term debt	325	547	81
Payments of long term debt	(519)	(1,201)	(1,564)
Payments of deferred consideration for acquisitions	(8,678)	(6,705)	(6,252)
Proceeds from stock option exercises	980	19,165	14,462
Payment of stock issuance costs	(10)	0	0
Net cash provided by financing activities	4,284	12,065	331,683
Effect of exchange rate changes on cash and cash equivalents	1,027	(873)	209
Net increase (decrease) in cash and cash equivalents	5,504	(73,175)	108,316
Cash and cash equivalents
Beginning of period	62,607	135,782	27,466
End of period	68,111	62,607	135,782
Supplemental disclosure of cash flow information
Cash paid during the period for interest	617	964	1,195
Cash paid during the period for income taxes	566	10	1,165
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	0	18,766	9,149
Preferred stock received as consideration for collaboration amendments	0	120,000	0
Receivables converted to preferred stock	3,385	0	0
Stock and warrants issued in business combinations	16,997	0	126,863
Stock issued to acquire noncontrolling interests	5,082	0	9,412
Stock issued in asset acquisition	0	4,401	0
Contingent consideration assumed in asset acquisition	0	3,660	0
Stock issued as payment for contingent consideration	0	1,583	0
Noncash dividend to shareholders	22,385	0	172,419
Deferred consideration payable related to acquisition	0	0	1,992
Purchases of equipment included in accounts payable and other accrued liabilities	2,257	652	782
Receivable recorded in anticipation of dissolution of affiliate	2,598	0	0
Transfer of inventory to breeding stock	$ 0	$ 1,191	$ 0