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Mergers and Acquisitions - GenVec - Additional Information (Details) - GenVec, Inc. - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Business Acquisition [Line Items]      
Percentage of outstanding common stock acquired 100.00%    
Business combination, consideration paid, shares issued 684,240    
Collaboration agreement, percent of collaboration payments 50.00%    
Business combination, period subsequent to acquisition during which a portion of collaboration payments received will be paid to former stockholders of acquired entity 3 years    
Expected useful life of intangible asset 11 years    
Business Combination, Consideration Transferred $ 17,582    
Selling, general and administrative      
Business Acquisition [Line Items]      
Business combination, acquisition related cost   $ 507 $ 12