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Shareholders' Equity - Additional Information (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2017
Jan. 31, 2017
Aug. 31, 2015
Jun. 30, 2015
Jan. 31, 2015
Dec. 31, 2017
Dec. 31, 2015
Class of Stock [Line Items]              
Shares issued in public or private offerings, net of issuance costs, shares 1,207,980   5,609,756   4,312,500    
Value of shares issued in public or private offerings $ 13,686   $ 218,193   $ 110,041 $ 13,686 $ 328,234
Underwriting discounts and commissions     11,500   6,086    
Capitalized offering expenses     $ 306   $ 311    
Noncash dividend to shareholders           $ 0 172,419
Affiliates Of Third Security              
Class of Stock [Line Items]              
Shares issued in public or private offerings, net of issuance costs, shares         555,556    
AquaBounty Technologies, Inc.              
Class of Stock [Line Items]              
Noncash dividend, shares   1,776,557          
Noncash dividend to shareholders   $ 22,385          
ZIOPHARM Oncology, Inc.              
Class of Stock [Line Items]              
Noncash dividend, shares       17,830,305      
Realized investment gain             $ 81,401
Intrexon Stock Option Plans              
Class of Stock [Line Items]              
Adjustment due to dividend (in shares)           46,766 312,795
Adjustment due to dividend (in usd per share)           $ 31.11 $ 25.40