Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Cash flows from operating activities
Net loss	$ (92,875)	$ (145,362)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	22,881	17,657
Loss on disposal of property, plant and equipment	1,311	297
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock	(9,240)	45,388
Noncash dividend income	(12,303)	(3,676)
Amortization of premiums on investments	411	862
Equity in net loss of affiliates	11,273	16,951
Stock-based compensation expense	31,949	30,631
Shares issued as payment for services	8,440	8,284
Provision for bad debts	1,093	1,609
Deferred income taxes	(2,294)	(2,967)
Other noncash items	(1,848)	1,259
Changes in operating assets and liabilities:
Restricted cash	0	(6,987)
Receivables:
Trade	2,491	2,118
Related parties	(1,073)	7,438
Notes	0	(42)
Other	537	381
Inventory	3,418	4,683
Prepaid expenses and other	(516)	(985)
Other assets	(1,036)	2,134
Accounts payable	(3,756)	2,901
Accrued compensation and benefits	3,291	(8,001)
Other accrued liabilities	1,554	7,771
Deferred revenue	(35,281)	(14,099)
Deferred consideration	(313)	(630)
Related party payables	356	479
Other long term liabilities	1,271	126
Net cash used in operating activities	(70,259)	(31,780)
Cash flows from investing activities
Purchases of investments	0	(75,246)
Maturities of investments	136,300	71,987
Purchases of equity securities, preferred stock and warrants	(1,161)	(2,308)
Proceeds from sales of equity securities	235	0
Cash acquired in a business combination	2,054	0
Investments in affiliates	(10,639)	(9,415)
Cash paid in asset acquisition	(14,219)	(7,244)
Purchases of property, plant and equipment	(32,675)	(20,197)
Proceeds from sale of property, plant and equipment	1,423	243
Issuance of note receivable	(2,400)	(2,964)
Proceeds from repayment of note receivable	1,500	0
Net cash provided by (used in) investing activities	80,418	(45,144)
Cash flows from financing activities
Acquisitions of noncontrolling interests	(913)	0
Advances from lines of credit	4,563	2,308
Repayments of advances from lines of credit	(5,149)	(2,320)
Proceeds from long term debt	285	547
Payments of long term debt	(385)	(848)
Payments of deferred consideration for acquisitions	(8,678)	(6,705)
Proceeds from stock option exercises	867	18,180
Payment of stock issuance costs	(10)	0
Net cash provided by (used in) financing activities	(9,420)	11,162
Effect of exchange rate changes on cash and cash equivalents	870	(313)
Net increase (decrease) in cash and cash equivalents	1,609	(66,075)
Cash and cash equivalents
Beginning of period	62,607	135,782
End of period	64,216	69,707
Supplemental disclosure of cash flow information
Cash paid during the period for interest	534	875
Cash paid during the period for income taxes	497	0
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	0	18,766
Preferred stock received as consideration for collaboration amendments	0	120,000
Stock and warrants issued in business combinations	16,997	0
Stock issued to acquire noncontrolling interest	5,082	0
Stock issued in asset acquisition	0	4,401
Contingent consideration assumed in asset acquisition	0	3,660
Noncash dividend to shareholders	22,385	0
Purchases of equipment included in accounts payable and other accrued liabilities	$ 2,137	$ 926