Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities
Net loss	$ (52,039)	$ (115,351)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	14,891	11,674
Loss on disposal of property, plant and equipment	967	225
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock	(7,065)	45,800
Noncash dividend income	(7,980)	0
Amortization of premiums on investments	330	598
Equity in net loss of affiliates	8,280	10,696
Stock-based compensation expense	19,892	19,839
Shares issued as payment for services	5,710	5,689
Provision for bad debts	582	1,183
Deferred income taxes	(1,519)	(2,659)
Other noncash items	(3,606)	391
Receivables:
Trade	(1,702)	(2,463)
Related parties	(1,935)	9,203
Notes	0	(24)
Other	660	626
Inventory	2,000	2,071
Prepaid expenses and other	471	1,299
Other assets	(736)	2,697
Accounts payable	(3,792)	2,834
Accrued compensation and benefits	1,246	(9,543)
Other accrued liabilities	1,997	4,807
Deferred revenue	(25,794)	(6,078)
Related party payables	284	331
Other long term liabilities	609	106
Net cash used in operating activities	(48,249)	(16,049)
Cash flows from investing activities
Maturities of investments	88,000	41,987
Purchases of equity securities, preferred stock and warrants	(1,161)	(1,167)
Proceeds from sales of equity securities	235	0
Cash acquired in a business combination	2,054	0
Investments in affiliates	(4,579)	(5,054)
Cash paid in asset acquisition	(14,219)	(7,244)
Purchases of property, plant and equipment	(18,262)	(10,038)
Proceeds from sale of property, plant and equipment	1,115	140
Issuance of note receivable	(2,400)	0
Proceeds from repayment of note receivable	1,500	0
Net cash provided by investing activities	52,283	18,624
Cash flows from financing activities
Acquisitions of noncontrolling interests	(913)	0
Advances from lines of credit	3,324	1,540
Repayments of advances from lines of credit	(3,859)	(1,640)
Proceeds from long term debt	285	0
Payments of long term debt	(252)	(685)
Payments of deferred consideration for acquisitions	(1,991)	0
Proceeds from stock option exercises	678	17,671
Payment of stock issuance costs	(10)	0
Net cash provided by (used in) financing activities	(2,738)	16,886
Effect of exchange rate changes on cash and cash equivalents	457	(162)
Net increase in cash and cash equivalents	1,753	19,299
Cash and cash equivalents
Beginning of period	62,607	135,782
End of period	64,360	155,081
Supplemental disclosure of cash flow information
Cash paid during the period for interest	146	140
Cash paid during the period for income taxes	377	0
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	0	13,666
Preferred stock received as consideration for collaboration amendments	0	120,000
Stock and warrants issued in business combinations	16,997	0
Stock issued to acquire noncontrolling interest	5,082	0
Stock issued in asset acquisition	0	4,401
Contingent consideration assumed in asset acquisition	0	3,660
Noncash dividend to shareholders	22,385	0
Purchases of equipment included in accounts payable and other accrued liabilities	$ 3,562	$ 1,118