Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 285,318	$ 310,142
Current portion of deferred revenue	47,662	53,364
Long-term portion of deferred revenue	237,656	256,778
Deferred revenue	285,318	310,142
Upfront and milestone payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	278,262	297,867
Deferred revenue	278,262	297,867
Prepaid research and development services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	2,502	6,015
Deferred revenue	2,502	6,015
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	4,550	5,554
Deferred revenue	4,550	5,554
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	4	706
Deferred revenue	$ 4	$ 706