Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Mar. 31, 2017	Dec. 31, 2016
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 297,291	$ 310,142
Current portion of deferred revenue	50,333	53,364
Long-term portion of deferred revenue	246,958	256,778
Deferred revenue	297,291	310,142
Upfront and milestone payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	287,677	297,867
Deferred revenue	287,677	297,867
Prepaid research and development services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	3,899	6,015
Deferred revenue	3,899	6,015
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,613	5,554
Deferred revenue	5,613	5,554
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	102	706
Deferred revenue	$ 102	$ 706