Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Cash flows from operating activities
Net loss	$ (190,274)	$ (87,994)	$ (85,616)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	24,572	17,743	10,415
Loss on disposal of property, plant and equipment	666	633	208
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock	58,894	(66,876)	10,469
Noncash dividend income	(7,421)	0	0
Amortization of discount/premium on investments	1,070	642	1,357
Equity in net loss of affiliates	21,120	8,944	5,260
Stock-based compensation expense	42,202	38,667	21,849
Contribution of services by shareholder	0	0	1,991
Shares issued as payment for services	10,777	2,169	486
Shares issued as consideration for license agreement	0	59,579	0
Provision for bad debts	1,963	1,757	565
Deferred income taxes	(3,467)	1,117	0
Other noncash items	1,662	460	723
Changes in operating assets and liabilities:
Restricted cash	(6,987)	0	0
Receivables:
Trade	2,588	(12,138)	4,332
Related parties	6,804	(11,042)	(6,117)
Notes	(42)	0	(1)
Other	271	5,286	15
Inventory	3,807	(774)	(7,313)
Prepaid expenses and other	(932)	(2,729)	(465)
Other assets	2,189	(2,119)	80
Accounts payable	3,618	(3,263)	1,266
Accrued compensation and benefits	(12,402)	10,491	1,587
Other accrued liabilities	9,002	1,593	(586)
Deferred revenue	(25,481)	74,434	20,934
Deferred consideration	(630)	(943)	0
Related party payables	310	(64)	(1,137)
Other long term liabilities	146	96	(160)
Net cash provided by (used in) operating activities	(55,975)	35,669	(19,858)
Cash flows from investing activities
Purchases of investments	(75,246)	(181,572)	(60,478)
Sales of investments	0	0	9,100
Maturities of investments	101,987	88,000	122,992
Purchases of equity securities and warrants	(2,308)	(17,080)	(19,496)
Proceeds from sales of equity securities	280	0	0
Acquisitions of businesses, net of cash received	0	(123,928)	(67,577)
Acquisition of noncontrolling interest	0	(1,566)	0
Investments in affiliates	(11,542)	(13,442)	(2,875)
Cash paid in asset acquisition	(7,244)	0	0
Purchases of property, plant and equipment	(31,629)	(12,749)	(6,371)
Proceeds from sale of property, plant and equipment	274	626	176
Issuances of notes receivable	(2,964)	(600)	(1,500)
Proceeds from notes receivable	0	1,500	0
Net cash used in investing activities	(28,392)	(260,811)	(26,029)
Cash flows from financing activities
Proceeds from issuance of shares in a private placement	0	0	25,000
Proceeds from issuance of shares in public offerings, net of issuance costs	0	328,234	0
Advances from lines of credit	5,075	15,232	4,676
Repayments of advances from lines of credit	(4,816)	(16,944)	(6,494)
Proceeds from long term debt	547	81	268
Payments of long term debt	(1,201)	(1,564)	(679)
Payments of deferred consideration	(6,705)	(6,252)	0
Proceeds from stock option exercises	19,165	14,462	1,489
Payment of stock issuance costs	0	0	(256)
Net cash provided by financing activities	12,065	333,249	24,004
Effect of exchange rate changes on cash and cash equivalents	(873)	209	(160)
Net increase (decrease) in cash and cash equivalents	(73,175)	108,316	(22,043)
Cash and cash equivalents
Beginning of period	135,782	27,466	49,509
End of period	62,607	135,782	27,466
Supplemental disclosure of cash flow information
Cash paid during the period for interest	964	1,195	158
Cash paid during the period for income taxes	10	1,165	0
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	18,766	9,149	14,246
Preferred stock received as consideration for collaboration amendments	120,000	0	0
Stock issued in business combinations	0	126,863	51,682
Stock issued to acquire noncontrolling interest	0	9,412	0
Shares issued in asset acquisition	4,401	0	0
Contingent consideration assumed in asset acquisition	3,660	0	0
Shares issued as payment for contingent consideration	1,583	0	0
Noncash dividend to shareholders	0	172,419	0
Deferred consideration payable related to acquisition	0	1,992	20,115
Purchases of equipment included in accounts payable and other accrued liabilities	652	782	790
Transfer of inventory to breeding stock	$ 1,191	$ 0	$ 0