Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Deferred Revenue Arrangement [Line Items]
Current portion of deferred revenue	$ 53,364	$ 35,366
Long-term portion of deferred revenue	256,778	162,363
Deferred revenue	310,142	197,729
Upfront and milestone payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	297,867	181,331
Prepaid research and development services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	6,015	10,938
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,554	4,759
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 706	$ 701