Mergers and Acquisitions - ActoGeniX - Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015	Feb. 28, 2015	Dec. 31, 2014
Business Acquisition [Line Items]
Goodwill	$ 157,175	$ 165,169		$ 101,059
ActoGeniX NV
Business Acquisition [Line Items]
Cash			$ 3,180
Other receivables			305
Prepaid expenses and other			31
Property, plant and equipment			209
Intangible assets			68,100
Other non-current assets			23
Total assets acquired			71,848
Accounts payable			230
Accrued compensation and benefits			196
Other accrued liabilities			253
Deferred revenue			732
Deferred tax liabilities			612
Total liabilities assumed			2,023
Net assets acquired			69,825
Goodwill			2,649
Total consideration and fair value of noncontrolling interest			$ 72,474