Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Computed statutory income tax benefit	$ (66,011)	$ (29,573)	$ (29,144)
State and provincial income tax benefit, net of federal income taxes	(7,905)	(3,157)	(3,544)
Nondeductible stock based compensation	3,321	3,182	1,386
Nondeductible officer compensation	0	2,433	0
Contribution of services by shareholder	0	0	677
Research and development tax incentives	(6,350)	(348)	258
Acquisition and internal restructuring transaction costs	571	883	0
Enacted change in tax rates	0	(961)	0
U.S.-foreign rate differential	3,463	620	0
Other, net	1,485	(98)	1,503
Income tax reconciliation income tax benefit before valuation allowance, total	(71,426)	(27,019)	(28,864)
Change in valuation allowance for deferred tax assets	67,549	28,035	28,761
Total income tax expense (benefit)	$ (3,877)	$ 1,016	$ (103)