Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Cash flows from operating activities
Net loss	$ (145,362)	$ (54,719)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	17,657	12,202
Loss on disposal of property, plant and equipment	297	519
Unrealized and realized (appreciation) depreciation on equity securities	45,388	(64,392)
Noncash dividend income	(3,676)	0
Amortization of discount/premium on investments	862	298
Equity in net loss of affiliates	16,951	6,565
Stock-based compensation expense	30,631	26,524
Shares issued as payment for services	8,284	480
Shares issued as consideration for license agreement	0	59,579
Provision for bad debts	1,609	1,562
Deferred income taxes	(2,967)	374
Other noncash items	1,259	305
Changes in operating assets and liabilities:
Restricted cash	(6,987)	0
Receivables:
Trade	2,118	(12,014)
Related parties	7,438	(11,182)
Notes	(42)	1
Other	381	6,390
Inventory	4,683	3,451
Prepaid expenses and other	(985)	(4,005)
Other assets	2,134	(3,817)
Accounts payable	2,901	(3,560)
Accrued compensation and benefits	(8,001)	5,895
Other accrued liabilities	7,771	1,323
Deferred revenue	(14,099)	52,400
Deferred consideration	(630)	(943)
Related party payables	479	(67)
Other long term liabilities	126	168
Net cash provided by (used in) operating activities	(31,780)	23,337
Cash flows from investing activities
Purchases of investments	(75,246)	(181,572)
Maturities of investments	71,987	70,000
Purchases of equity securities and warrants	(2,308)	(17,080)
Acquisitions of businesses, net of cash received	0	(114,480)
Acquisition of noncontrolling interest	0	(1,566)
Investments in affiliates	(9,415)	(4,699)
Cash paid in asset acquisition	(7,244)	0
Purchases of property, plant and equipment	(20,197)	(9,841)
Proceeds from sale of property, plant and equipment	243	420
Issuances of notes receivable	(2,964)	0
Proceeds from notes receivable	0	1,500
Net cash used in investing activities	(45,144)	(257,318)
Cash flows from financing activities
Proceeds from issuance of shares in public offerings, net of issuance costs	0	328,234
Advances from lines of credit	2,308	13,719
Repayments of advances from lines of credit	(2,320)	(15,517)
Proceeds from long term debt	547	81
Payments of long term debt	(848)	(1,032)
Payments of deferred consideration	(6,705)	(6,252)
Proceeds from stock option exercises	18,180	12,208
Net cash provided by financing activities	11,162	331,441
Effect of exchange rate changes on cash and cash equivalents	(313)	507
Net increase (decrease) in cash and cash equivalents	(66,075)	97,967
Cash and cash equivalents
Beginning of period	135,782	27,466
End of period	69,707	125,433
Supplemental disclosure of cash flow information
Cash paid during the period for interest	875	1,119
Cash paid during the period for income taxes	0	1,165
Significant noncash financing and investing activities
Note receivable as consideration for collaboration agreement	0	5,000
Stock received as consideration for collaboration agreements	18,766	4,667
Preferred stock received as consideration for collaboration amendments	120,000	0
Stock issued in business combinations	0	126,863
Stock issued to acquire noncontrolling interest	0	9,412
Stock issued in asset acquisition	4,401	0
Contingent consideration assumed in asset acquisition	3,660	0
Noncash dividend to shareholders	0	172,419
Deferred consideration payable related to acquisition	0	11,440
Purchases of equipment included in accounts payable and other accrued liabilities	$ 926	$ 533