Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 322,397	$ 197,729
Current portion of deferred revenue	54,937	35,366
Long-term portion of deferred revenue	267,460	162,363
Deferred revenue	322,397	197,729
Upfront and milestone payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	309,126	181,331
Deferred revenue	309,126	181,331
Prepaid research and development services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	7,057	10,938
Deferred revenue	7,057	10,938
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,594	4,759
Deferred revenue	5,594	4,759
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	620	701
Deferred revenue	$ 620	$ 701