Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015
Cash flows from operating activities
Net loss	$ (115,351)	$ (15,690)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	11,674	7,358
Loss on disposal of property, plant and equipment	225	201
Unrealized and realized (appreciation) depreciation on equity securities	45,800	(94,845)
Amortization of discount/premium on investments	598	196
Equity in net loss of affiliates	10,696	4,136
Stock-based compensation expense	19,839	18,139
Shares issued as payment for services	5,689	480
Shares issued as consideration for license agreement	0	59,579
Provision for bad debts	1,183	984
Deferred income taxes	(2,659)	952
Other noncash items	391	542
Receivables:
Trade	(2,463)	(127,516)
Related parties	9,203	213
Note	(24)	(20)
Other	626	210
Inventory	2,071	(1,212)
Prepaid expenses and other	1,299	(1,669)
Other assets	2,697	(4,876)
Accounts payable	2,834	(125)
Accrued compensation and benefits	(9,543)	4,099
Other accrued liabilities	4,807	839
Deferred revenue	(6,078)	60,909
Related party payables	331	57,370
Other long term liabilities	106	188
Net cash used in operating activities	(16,049)	(29,558)
Cash flows from investing activities
Maturities of investments	41,987	48,000
Purchases of equity securities and warrants	(1,167)	(14,900)
Acquisitions of businesses, net of cash received	0	(39,501)
Acquisition of noncontrolling interest	0	(1,566)
Investments in affiliates	(5,054)	(3,334)
Cash paid in asset acquisition	(7,244)	0
Purchases of property, plant and equipment	(10,038)	(6,740)
Proceeds from sale of property, plant and equipment	140	233
Net cash provided by (used in) investing activities	18,624	(17,808)
Cash flows from financing activities
Proceeds from issuance of shares in public offerings, net of issuance costs	0	110,041
Advances from lines of credit	1,540	11,680
Repayments of advances from lines of credit	(1,640)	(13,080)
Proceeds from long term debt	0	44
Payments of long term debt	(685)	(678)
Proceeds from stock option exercises	17,671	10,382
Net cash provided by financing activities	16,886	118,389
Effect of exchange rate changes on cash and cash equivalents	(162)	410
Net increase in cash and cash equivalents	19,299	71,433
Cash and cash equivalents
Beginning of period	135,782	27,466
End of period	155,081	98,899
Supplemental disclosure of cash flow information
Cash paid during the period for interest	140	99
Significant noncash financing and investing activities
Note receivable as consideration for collaboration agreement	0	5,000
Stock received as consideration for collaboration agreements	13,666	0
Preferred stock received as consideration for collaboration amendments	120,000	0
Stock issued in business combinations	0	70,668
Stock issued to acquire noncontrolling interest	0	9,412
Stock issued in asset acquisition	4,401	0
Contingent consideration assumed in asset acquisition	3,660	0
Noncash dividend to shareholders	0	172,419
Purchases of equipment included in accounts payable and other accrued liabilities	$ 1,118	$ 1,064