Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities
Net income (loss)	$ (65,320)	$ 25,804
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	5,648	3,549
Loss on disposal of property, plant and equipment	185	92
Unrealized (appreciation) depreciation on equity securities	22,331	(115,454)
Amortization of discount/premium on investments	320	124
Equity in net loss of affiliates	5,643	1,956
Stock-based compensation expense	13,188	10,259
Shares issued as compensation for services	3,083	480
Shares issued as consideration for license agreement	0	59,579
Provision for bad debts	840	393
Deferred income taxes	(2,188)	795
Other noncash items	193	264
Receivables:
Trade	3,022	(815)
Related parties	7,578	2,807
Note	(12)	(16)
Other	(168)	67
Inventory	1,485	(382)
Prepaid expenses and other	143	(292)
Other assets	839	(1,216)
Accounts payable	2,393	672
Accrued compensation and benefits	(10,773)	(297)
Other accrued liabilities	4,724	1,210
Deferred revenue	3,050	(2,621)
Related party payables	208	(156)
Other long term liabilities	(21)	157
Net cash used in operating activities	(3,609)	(13,041)
Cash flows from investing activities
Maturities of investments	18,000	24,000
Purchases of equity securities and warrants	0	(14,900)
Acquisitions of businesses, net of cash received	0	(29,559)
Acquisition of noncontrolling interest	0	(1,566)
Investments in affiliates	(2,721)	(1,491)
Cash paid in asset acquisition	(7,244)	0
Purchases of property, plant and equipment	(4,257)	(2,711)
Proceeds from sale of property, plant and equipment	102	194
Net cash provided by (used in) investing activities	3,880	(26,033)
Cash flows from financing activities
Proceeds from issuance of shares in public offerings, net of issuance costs	0	110,041
Advances from lines of credit	812	5,559
Repayments of advances from lines of credit	(837)	(7,211)
Proceeds from long term debt	0	44
Payments of long term debt	(160)	(341)
Proceeds from stock option exercises	9,777	2,567
Net cash provided by financing activities	9,592	110,659
Effect of exchange rate changes on cash and cash equivalents	88	(36)
Net increase in cash and cash equivalents	9,951	71,549
Cash and cash equivalents
Beginning of period	135,782	27,466
End of period	145,733	99,015
Supplemental disclosure of cash flow information
Cash paid during the period for interest	70	84
Significant noncash financing and investing activities
Stock received as consideration for collaboration agreements	9,333	0
Stock issued in business combinations	0	39,735
Stock issued to acquire noncontrolling interest	0	9,412
Stock issued in asset acquisition	4,401	0
Contingent consideration assumed in asset acquisition	3,660	0
Purchases of equipment included in accounts payable and other accrued liabilities	839	0
Proceeds from stock option exercises included in other receivables	$ 3,553	$ 0