Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 210,238	$ 197,729
Current portion of deferred revenue	37,695	35,366
Long-term portion of deferred revenue	172,543	162,363
Upfront and Milestone Payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	194,849	181,331
Prepaid Research and Development Services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	9,439	10,938
Prepaid Product and Service Revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	5,201	4,759
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 749	$ 701