Collaboration and Licensing Revenue - Summary of Deferred Revenue (Detail) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Deferred Revenue Arrangement [Line Items]
Current portion of deferred revenue	$ 35,366	$ 16,522
Long-term portion of deferred revenue	162,363	96,687
Deferred revenue	197,729	113,209
Upfront and milestone payments
Deferred Revenue Arrangement [Line Items]
Deferred revenue	181,331	107,228
Prepaid research and development services
Deferred Revenue Arrangement [Line Items]
Deferred revenue	10,938	1,045
Prepaid product and service revenues
Deferred Revenue Arrangement [Line Items]
Deferred revenue	4,759	4,365
Other
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 701	$ 571