Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Cash flows from operating activities
Net loss	$ (85,616)	$ (40,908)	$ (81,874)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	10,415	7,205	7,984
Loss on disposal of property, plant and equipment	208	349	101
Unrealized (appreciation) depreciation on equity securities	10,469	(10,443)	6,290
Amortization of discount/premium of investments	1,357	716	0
Collaboration revenue recognized upon achievement of milestone	0	0	(3,591)
Equity in net loss of affiliates	5,260	606	274
Gain on previously held equity investment	0	(7,415)	0
Stock-based compensation expense	21,849	2,921	1,458
Contribution of services by shareholder	1,991	1,550	1,550
Shares issued to nonemployee members of the Board of Directors	486	124	93
Provision for bad debts	565	0	0
Other noncash items	723	(75)	0
Receivables:
Trade	4,332	(644)	(121)
Related parties	(6,117)	(4,967)	(93)
Note	(1)	0	0
Other	15	(542)	1,015
Inventory	(7,313)	0	0
Prepaid expenses and other	(465)	(347)	(413)
Other assets	80	(18)	658
Accounts payable	1,266	(43)	(1,229)
Accrued compensation and benefits	1,587	1,301	2,441
Other accrued liabilities	(586)	1,558	(806)
Deferred revenue	20,934	(4,368)	4,997
Related party payables	(1,137)	6	(180)
Other long term liabilities	(160)	(249)	(83)
Net cash used in operating activities	(19,858)	(53,683)	(61,529)
Cash flows from investing activities
Purchases of investments	(60,478)	(233,979)	(2)
Sales of investments	9,100	0	0
Maturities of investments	122,992	44,996	0
Purchases of equity securities	(19,496)	(28,650)	(10,000)
Acquisitions of businesses, net of cash received	(67,577)	517	0
Investments in affiliates	(2,875)	(5,000)	(6,000)
Purchases of property, plant and equipment	(6,371)	(1,527)	(7,491)
Proceeds from sale of property, plant and equipment	176	480	23
Issuance of notes receivable	(1,500)	(1,000)	(200)
Proceeds from notes receivable	0	500	34
Net cash used in investing activities	(26,029)	(223,663)	(23,636)
Cash flows from financing activities
Proceeds from IPO, net of issuance costs	0	168,801	0
Proceeds from issuance of shares in private placement	25,000	0	0
Settlement of fractional shares	0	(5)	0
Advances from lines of credit	4,676	0	0
Repayments of advances from lines of credit	(6,494)	0	0
Payments of capital lease obligations	(32)	(51)	(77)
Proceeds from long term debt	268	493	0
Payments of long term debt	(647)	(53)	0
Proceeds from stock option exercises	1,489	414	473
Payment of issuance costs	(256)	(3,148)	(16)
Net cash provided by financing activities	24,004	316,451	75,940
Effect of exchange rate changes on cash and cash equivalents	(160)	1	0
Net increase (decrease) in cash and cash equivalents	(22,043)	39,106	(9,225)
Cash and cash equivalents
Beginning of period	49,509	10,403	19,628
End of period	27,466	49,509	10,403
Supplemental disclosure of cash flow information
Cash paid during the period for interest	158	51	12
Significant noncash financing and investing activities
Accretion of dividends on redeemable convertible preferred shares	0	18,391	21,994
Stock received as upfront consideration for collaboration agreements	14,246	19,303	21,979
Stock received as consideration upon achievement of milestone	0	0	18,330
Common stock issued in acquisitions	51,682	0	0
Deferred consideration payable related to acquisition	20,115	0	0
Accrued investment in affiliate	0	1,500	0
Purchases of equipment included in accounts payable and other accrued liabilities	790	361	24
Series E Redeemable Convertible Preferred Stock
Cash flows from financing activities
Proceeds from issuance of redeemable convertible preferred shares	0	0	75,560
Significant noncash financing and investing activities
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock		219,332
Accretion of dividends on redeemable convertible preferred shares		7,931	10,465
Series E Redeemable Convertible Preferred Stock | Subscriptions Payable
Significant noncash financing and investing activities
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock	0	0	7,440
Series F Redeemable Convertible Preferred Stock
Cash flows from financing activities
Proceeds from issuance of redeemable convertible preferred shares	0	150,000	0
Significant noncash financing and investing activities
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock		150,075
Accretion of dividends on redeemable convertible preferred shares		3,224
Common Stock | Common shares issuable upon conversion of all Series Preferred
Significant noncash financing and investing activities
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock	$ 0	$ 571,898	$ 0