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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Pay vs Performance Disclosure        
Pay vs Performance Disclosure, Table
PAY VERSUS PERFORMANCE
In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and Non-PEO NEOs and Company performance for the fiscal years listed below. For the most recently completed fiscal year, we did not use any financial performance measure to link Compensation Actually Paid to our NEOs to the Company’s performance; accordingly, this disclosure does not present a company-selected measure in the table below nor a tabular list of our most important performance measures, as permitted by the Securities and Exchange Commission. For further information regarding our performance-based approach to executive compensation and how the Company aligns executive compensation with the Company’s performance, see “Compensation Discussion and Analysis.”
Year
​ ​
Summary
Compensation
Table Total
for PEO(1)
($)
​ ​
Compensation
Actually Paid
to PEO(1)(2)(3)
($)
​ ​
Average
Summary
Compensation
Table Total
for Non-PEO
NEOs(1)
($)
​ ​
Average
Compensation
Actually Paid
to Non-PEO
NEOs(1)(2)(3)
($)
​ ​
Value of Initial
Fixed $100
Investment
based on:(4)
​ ​
Net Income
(Loss)
($ Millions)(5)
​
​
TSR
($)
​ ​
Peer
Group
TSR
($)
​
2023
​ ​ ​ ​ 3,719,061 ​ ​ ​ ​ ​ 3,730,478 ​ ​ ​ ​ ​ 1,026,666 ​ ​ ​ ​ ​ 1,042,395 ​ ​ ​ ​ ​ 24.45 ​ ​ ​ ​ ​ 118.87 ​ ​ ​ ​ ​ (95.9) ​ ​
2022
​ ​ ​ ​ 3,497,622 ​ ​ ​ ​ ​ (1,088,019) ​ ​ ​ ​ ​ 892,363 ​ ​ ​ ​ ​ 601,344 ​ ​ ​ ​ ​ 27.74 ​ ​ ​ ​ ​ 113.65 ​ ​ ​ ​ ​ 28.3 ​ ​
2021
​ ​ ​ ​ 2,516,170 ​ ​ ​ ​ ​ (16,112,693) ​ ​ ​ ​ ​ 611,020 ​ ​ ​ ​ ​ 230,396 ​ ​ ​ ​ ​ 67.70 ​ ​ ​ ​ ​ 126.45 ​ ​ ​ ​ ​ (92.2) ​ ​
2020
​ ​ ​ ​ 20,409,916 ​ ​ ​ ​ ​ 41,484,902 ​ ​ ​ ​ ​ 1,168,689 ​ ​ ​ ​ ​ 1,740,335 ​ ​ ​ ​ ​ 186.13 ​ ​ ​ ​ ​ 126.42 ​ ​ ​ ​ ​ (170.5) ​ ​
​
(1)
Helen Sabzevari was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
​
​
2020
​ ​
2021
​ ​
2022-2023
​
​
Donald P. Lehr
​ ​
Harry Thomasian Jr.
​ ​
Harry Thomasian Jr.
​
​
Jeffery Perez
​ ​
Donald P. Lehr
​ ​
Donald P. Lehr
​
​
Rick Sterling
​ ​
Jeffery Perez
​ ​
Jeffery Perez
​
​
Randal Kirk
​ ​
Rick Sterling
​ ​
Rutul Shah
​
​ ​ ​ ​
Brad Osborne
​ ​ ​ ​
​ ​ ​ ​
James V. Lambert
​ ​ ​ ​
​
(2)
The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
​
(3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
​
Year
​ ​
Summary
Compensation
Table
Total for PEO
($)
​ ​
Exclusion of
Stock Awards
and Option
Awards for
PEO
($)
​ ​
Inclusion
of Equity
Values for
PEO
($)
​ ​
Compensation
Actually
Paid to
PEO
($)
​
2023
​ ​ ​ ​ 3,719,061 ​ ​ ​ ​ ​ (2,700,681) ​ ​ ​ ​ ​ 2,712,098 ​ ​ ​ ​ ​ 3,730,478 ​ ​
Year
​ ​
Average
Summary
Compensation
Table Total
for Non-PEO
NEOS
($)
​ ​
Average
Exclusion of
Stock Awards
and Option
Awards for
Non-PEO
NEOs
($)
​ ​
Average
Inclusion of
Equity Values
for Non-PEO
NEOs
($)
​ ​
Average
Compensation
Actually
Paid to
Non-PEO
NEOs
($)
​
2023
​ ​ ​ ​ 1,026,666 ​ ​ ​ ​ ​ (496,530) ​ ​ ​ ​ ​ 512,259 ​ ​ ​ ​ ​ 1,042,395 ​ ​
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year
​ ​
Year-End
Fair Value
of Equity
Awards
Granted
During
Year That
Remained
Unvested
as of Last
Day of Year
for PEO
($)
​ ​
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of Unvested
Equity Awards
for PEO
($)
​ ​
Vesting-Date
Fair Value
of Equity
Awards
Granted
During
Year that
Vested During
Year for PEO
($)
​ ​
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting
Date of
Unvested
Equity Awards
that Vested
During Year
for PEO
($)
​ ​
Total – 
Inclusion of
Equity
Values
for PEO
($)
​
2023
​ ​ ​ ​ 1,794,704 ​ ​ ​ ​ ​ (219,748) ​ ​ ​ ​ ​ 1,069,717 ​ ​ ​ ​ ​ 67,425 ​ ​ ​ ​ ​ 2,712,098 ​ ​
Year
​ ​
Average
Year-End
Fair Value
of Equity
Awards
Granted
During
Year That
Remained
Unvested as of
Last Day of
Year for
Non-PEO
NEOs
($)
​ ​
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Last Day of
Year of
Unvested
Equity
Awards for
Non-PEO
NEOs
($)
​ ​
Average
Vesting-Date
Fair Value
of Equity
Awards
Granted
During
Year that
Vested During
Year for
Non-PEO
NEOs ($)
​ ​
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting Date
of Unvested
Equity Awards
that Vested
During Year
for Non-PEO
NEOs
($)
​ ​
Total – 
Average
Inclusion
of Equity
Values for
Non-PEO
NEOs
($)
​
2023
​ ​ ​ ​ 393,948 ​ ​ ​ ​ ​ (24,822) ​ ​ ​ ​ ​ 139,775 ​ ​ ​ ​ ​ 3,358 ​ ​ ​ ​ ​ 512,259 ​ ​
​
(4)
The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
​
(5)
Reflects “Net Income (loss)” for each applicable year as set forth in our Consolidated Statements of Operations included in our Annual Report on Form 10-K for each of the applicable years.
​
      
Named Executive Officers, Footnote
(1)
Helen Sabzevari was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
​
​
2020
​ ​
2021
​ ​
2022-2023
​
​
Donald P. Lehr
​ ​
Harry Thomasian Jr.
​ ​
Harry Thomasian Jr.
​
​
Jeffery Perez
​ ​
Donald P. Lehr
​ ​
Donald P. Lehr
​
​
Rick Sterling
​ ​
Jeffery Perez
​ ​
Jeffery Perez
​
​
Randal Kirk
​ ​
Rick Sterling
​ ​
Rutul Shah
​
​ ​ ​ ​
Brad Osborne
​ ​ ​ ​
​ ​ ​ ​
James V. Lambert
​ ​ ​ ​
     
Changed Peer Group, Footnote
(4)
The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report for the year ended December 31, 2023. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance 		     
PEO Total Compensation Amount $ 3,719,061 $ 3,497,622 $ 2,516,170 $ 20,409,916
PEO Actually Paid Compensation Amount $ 3,730,478 (1,088,019) (16,112,693) 41,484,902
Adjustment To PEO Compensation, Footnote
(3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
​
Year
​ ​
Summary
Compensation
Table
Total for PEO
($)
​ ​
Exclusion of
Stock Awards
and Option
Awards for
PEO
($)
​ ​
Inclusion
of Equity
Values for
PEO
($)
​ ​
Compensation
Actually
Paid to
PEO
($)
​
2023
​ ​ ​ ​ 3,719,061 ​ ​ ​ ​ ​ (2,700,681) ​ ​ ​ ​ ​ 2,712,098 ​ ​ ​ ​ ​ 3,730,478 ​ ​
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year
​ ​
Year-End
Fair Value
of Equity
Awards
Granted
During
Year That
Remained
Unvested
as of Last
Day of Year
for PEO
($)
​ ​
Change in
Fair Value
from Last
Day of Prior
Year to Last
Day of Year
of Unvested
Equity Awards
for PEO
($)
​ ​
Vesting-Date
Fair Value
of Equity
Awards
Granted
During
Year that
Vested During
Year for PEO
($)
​ ​
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting
Date of
Unvested
Equity Awards
that Vested
During Year
for PEO
($)
​ ​
Total – 
Inclusion of
Equity
Values
for PEO
($)
​
2023
​ ​ ​ ​ 1,794,704 ​ ​ ​ ​ ​ (219,748) ​ ​ ​ ​ ​ 1,069,717 ​ ​ ​ ​ ​ 67,425 ​ ​ ​ ​ ​ 2,712,098 ​ ​
     
Non-PEO NEO Average Total Compensation Amount $ 1,026,666 892,363 611,020 1,168,689
Non-PEO NEO Average Compensation Actually Paid Amount $ 1,042,395 601,344 230,396 1,740,335
Adjustment to Non-PEO NEO Compensation Footnote
(3)
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table.
Year
​ ​
Average
Summary
Compensation
Table Total
for Non-PEO
NEOS
($)
​ ​
Average
Exclusion of
Stock Awards
and Option
Awards for
Non-PEO
NEOs
($)
​ ​
Average
Inclusion of
Equity Values
for Non-PEO
NEOs
($)
​ ​
Average
Compensation
Actually
Paid to
Non-PEO
NEOs
($)
​
2023
​ ​ ​ ​ 1,026,666 ​ ​ ​ ​ ​ (496,530) ​ ​ ​ ​ ​ 512,259 ​ ​ ​ ​ ​ 1,042,395 ​ ​
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
Year
​ ​
Average
Year-End
Fair Value
of Equity
Awards
Granted
During
Year That
Remained
Unvested as of
Last Day of
Year for
Non-PEO
NEOs
($)
​ ​
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Last Day of
Year of
Unvested
Equity
Awards for
Non-PEO
NEOs
($)
​ ​
Average
Vesting-Date
Fair Value
of Equity
Awards
Granted
During
Year that
Vested During
Year for
Non-PEO
NEOs ($)
​ ​
Average
Change in
Fair Value
from Last
Day of Prior
Year to
Vesting Date
of Unvested
Equity Awards
that Vested
During Year
for Non-PEO
NEOs
($)
​ ​
Total – 
Average
Inclusion
of Equity
Values for
Non-PEO
NEOs
($)
​
2023
​ ​ ​ ​ 393,948 ​ ​ ​ ​ ​ (24,822) ​ ​ ​ ​ ​ 139,775 ​ ​ ​ ​ ​ 3,358 ​ ​ ​ ​ ​ 512,259 ​ ​
​
      
Compensation Actually Paid vs. Total Shareholder Return
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”)
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the Company cumulative TSR over the four most recently completed fiscal years and the NASDAQ Biotechnology Index TSR over the same period.
[MISSING IMAGE: bc_tsr-4clr.jpg]
     
Compensation Actually Paid vs. Net Income
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net Income (loss)
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our Net Income (loss) during the four most recently completed fiscal years.
[MISSING IMAGE: bc_netincome-4clr.jpg]
     
Total Shareholder Return Vs Peer Group
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”)
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, the Company cumulative TSR over the four most recently completed fiscal years and the NASDAQ Biotechnology Index TSR over the same period.
[MISSING IMAGE: bc_tsr-4clr.jpg]
     
Total Shareholder Return Amount $ 24.45 27.74 67.7 186.13
Peer Group Total Shareholder Return Amount 118.87 113.65 126.45 126.42
Net Income (Loss) $ (95,900,000) $ 28,300,000 $ (92,200,000) $ (170,500,000)
PEO Name Helen Sabzevari      
PEO | Exclusion of Stock Awards and Option Awards        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ (2,700,681)      
PEO | Inclusion of Equity Values        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 2,712,098      
PEO | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 1,794,704      
PEO | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (219,748)      
PEO | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 1,069,717      
PEO | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 67,425      
Non-PEO NEO | Exclusion of Stock Awards and Option Awards        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (496,530)      
Non-PEO NEO | Inclusion of Equity Values        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 512,259      
Non-PEO NEO | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 393,948      
Non-PEO NEO | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (24,822)      
Non-PEO NEO | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 139,775      
Non-PEO NEO | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ 3,358