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Document and Entity Information - USD ($)
 12 Months Ended
Dec. 31, 2021
Mar. 25, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Title of 12(g) Security Common Stock, $0.001 par value per share    
Security Exchange Name NONE    
Entity Registrant Name INTERNATIONAL STEM CELL CORPORATION    
Entity Central Index Key 0001355790    
Current Fiscal Year End Date --12-31    
Entity Current Reporting Status Yes    
Entity Voluntary Filers No    
Entity Well Known Seasoned Issuer No    
Entity Filer Category Non-accelerated Filer    
Entity Shell Company false    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity File Number 0-51891    
Entity Tax Identification Number 20-4494098    
Entity Address, Address Line One 9745 Businesspark Ave    
Entity Address, City or Town San Diego    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92131    
City Area Code 760    
Local Phone Number 940-6383    
Entity Public Float     $ 2,518,900
Entity Common Stock, Shares Outstanding   8,004,389  
Entity Incorporation, State or Country Code DE    
Entity Interactive Data Current Yes    
Document Annual Report true    
Document Transition Report false    
ICFR Auditor Attestation Flag false    
Auditor Name BDO USA, LLP    
Auditor Location San Diego, California    
Auditor Firm ID 243    
Trading Symbol ISCO    
Documents Incorporated by Reference

Information from portions of the registrant’s definitive Proxy Statement for its Annual Meeting of Stockholders to be held in 2022 is incorporated by reference into Part III of this Form 10-K.