3.22.1 html 183 348 1 false 76 0 false 12 false false R1.htm 100000 - Document - Document and Entity Information Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DocumentDocumentAndEntityInformation Document and Entity Information Cover 1 false false R2.htm 100010 - Statement - Consolidated Balance Sheets Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/StatementConsolidatedBalanceSheets Consolidated Balance Sheets Statements 2 false false R3.htm 100020 - Statement - Consolidated Balance Sheets (Parenthetical) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/StatementConsolidatedBalanceSheetsParenthetical Consolidated Balance Sheets (Parenthetical) Statements 3 false false R4.htm 100030 - Statement - Consolidated Statements of Operations Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/StatementConsolidatedStatementsOfOperations Consolidated Statements of Operations Statements 4 false false R5.htm 100040 - Statement - Consolidated Statements of Changes in Redeemable Convertible Preferred Stock and Stockholders' Deficit Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/StatementConsolidatedStatementsOfChangesInRedeemableConvertiblePreferredStockAndStockholdersDeficit Consolidated Statements of Changes in Redeemable Convertible Preferred Stock and Stockholders' Deficit Statements 5 false false R6.htm 100050 - Statement - Consolidated Statements of Cash Flows Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/StatementConsolidatedStatementsOfCashFlows Consolidated Statements of Cash Flows Statements 6 false false R7.htm 100060 - Disclosure - Description of Business and Summary of Significant Accounting Policies Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPolicies Description of Business and Summary of Significant Accounting Policies Notes 7 false false R8.htm 100070 - Disclosure - Inventory Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureInventory Inventory Notes 8 false false R9.htm 100080 - Disclosure - Property and Equipment Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePropertyAndEquipment Property and Equipment Notes 9 false false R10.htm 100090 - Disclosure - Intangible Assets Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssets Intangible Assets Notes 10 false false R11.htm 100100 - Disclosure - Paycheck Protection Program Loan Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePaycheckProtectionProgramLoan Paycheck Protection Program Loan Notes 11 false false R12.htm 100110 - Disclosure - Convertible Preferred Stock Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStock Convertible Preferred Stock Notes 12 false false R13.htm 100120 - Disclosure - Stockholders' Deficit Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficit Stockholders' Deficit Notes 13 false false R14.htm 100130 - Disclosure - Equity Incentive Plans Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlans Equity Incentive Plans Notes 14 false false R15.htm 100140 - Disclosure - Related Party Transactions Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureRelatedPartyTransactions Related Party Transactions Notes 15 false false R16.htm 100150 - Disclosure - Income Taxes Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxes Income Taxes Notes 16 false false R17.htm 100160 - Disclosure - Commitments and Contingencies Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingencies Commitments and Contingencies Notes 17 false false R18.htm 100170 - Disclosure - Segments and Geographic Information Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformation Segments and Geographic Information Notes 18 false false R19.htm 100180 - Disclosure - Subsequent Events Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSubsequentEvents Subsequent Events Notes 19 false false R20.htm 100190 - Disclosure - Description of Business and Summary of Significant Accounting Policies (Policies) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesPolicies Description of Business and Summary of Significant Accounting Policies (Policies) Policies http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPolicies 20 false false R21.htm 100200 - Disclosure - Description of Business and Summary of Significant Accounting Policies (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesTables Description of Business and Summary of Significant Accounting Policies (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPolicies 21 false false R22.htm 100210 - Disclosure - Inventory (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureInventoryTables Inventory (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureInventory 22 false false R23.htm 100220 - Disclosure - Property and Equipment (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePropertyAndEquipmentTables Property and Equipment (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePropertyAndEquipment 23 false false R24.htm 100230 - Disclosure - Intangible Assets (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssetsTables Intangible Assets (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssets 24 false false R25.htm 100240 - Disclosure - Convertible Preferred Stock (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStockTables Convertible Preferred Stock (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStock 25 false false R26.htm 100250 - Disclosure - Stockholders' Deficit (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficitTables Stockholders' Deficit (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficit 26 false false R27.htm 100260 - Disclosure - Equity Incentive Plans (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansTables Equity Incentive Plans (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlans 27 false false R28.htm 100270 - Disclosure - Income Taxes (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxesTables Income Taxes (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxes 28 false false R29.htm 100280 - Disclosure - Commitments and Contingencies (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingenciesTables Commitments and Contingencies (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingencies 29 false false R30.htm 100290 - Disclosure - Segments and Geographic Information (Tables) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformationTables Segments and Geographic Information (Tables) Tables http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformation 30 false false R31.htm 100300 - Disclosure - Description of Business and Summary of Significant Accounting Policies - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesAdditionalInformationDetail Description of Business and Summary of Significant Accounting Policies - Additional Information (Detail) Details 31 false false R32.htm 100310 - Disclosure - Description of Business and Summary of Significant Accounting Policies - Summary of Revenue Disaggregated by Segment, Product and Geography (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesSummaryOfRevenueDisaggregatedBySegmentProductAndGeographyDetail Description of Business and Summary of Significant Accounting Policies - Summary of Revenue Disaggregated by Segment, Product and Geography (Detail) Details 32 false false R33.htm 100320 - Disclosure - Description of Business and Summary of Significant Accounting Policies - Summary of Antidilutive Securities not Included in Diluted Net Loss Per Share Calculation (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureDescriptionOfBusinessAndSummaryOfSignificantAccountingPoliciesSummaryOfAntidilutiveSecuritiesNotIncludedInDilutedNetLossPerShareCalculationDetail Description of Business and Summary of Significant Accounting Policies - Summary of Antidilutive Securities not Included in Diluted Net Loss Per Share Calculation (Detail) Details 33 false false R34.htm 100330 - Disclosure - Inventory - Summary of the Components of Inventories (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureInventorySummaryOfComponentsOfInventoriesDetail Inventory - Summary of the Components of Inventories (Detail) Details 34 false false R35.htm 100350 - Disclosure - Inventory - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureInventoryAdditionalInformationDetail Inventory - Additional Information (Detail) Details 35 false false R36.htm 100360 - Disclosure - Property and Equipment - Summary of Property and Equipment (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePropertyAndEquipmentSummaryOfPropertyAndEquipmentDetail Property and Equipment - Summary of Property and Equipment (Detail) Details 36 false false R37.htm 100370 - Disclosure - Property and Equipment - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePropertyAndEquipmentAdditionalInformationDetail Property and Equipment - Additional Information (Detail) Details 37 false false R38.htm 100380 - Disclosure - Intangible Assets - Summary of Intangible Assets (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssetsSummaryOfIntangibleAssetsDetail Intangible Assets - Summary of Intangible Assets (Detail) Details 38 false false R39.htm 100400 - Disclosure - Intangible Assets - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssetsAdditionalInformationDetail Intangible Assets - Additional Information (Detail) Details 39 false false R40.htm 100410 - Disclosure - Intangible Assets - Summary of Future Amortization Expense Related to Intangible Assets Subject to Amortization (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIntangibleAssetsSummaryOfFutureAmortizationExpenseRelatedToIntangibleAssetsSubjectToAmortizationDetail Intangible Assets - Summary of Future Amortization Expense Related to Intangible Assets Subject to Amortization (Detail) Details 40 false false R41.htm 100420 - Disclosure - Paycheck Protection Program Loan - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosurePaycheckProtectionProgramLoanAdditionalInformationDetail Paycheck Protection Program Loan - Additional Information (Detail) Details 41 false false R42.htm 100430 - Disclosure - Convertible Preferred Stock - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStockAdditionalInformationDetail Convertible Preferred Stock - Additional Information (Detail) Details 42 false false R43.htm 100440 - Disclosure - Convertible Preferred Stock - Schedule of Authorized, Issued and Outstanding Shares of Non-redeemable Convertible Preferred Stock (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStockScheduleOfAuthorizedIssuedAndOutstandingSharesOfNonRedeemableConvertiblePreferredStockDetail Convertible Preferred Stock - Schedule of Authorized, Issued and Outstanding Shares of Non-redeemable Convertible Preferred Stock (Detail) Details 43 false false R44.htm 100450 - Disclosure - Convertible Preferred Stock - Description of Convertible Preferred Stock - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStockDescriptionOfConvertiblePreferredStockAdditionalInformationDetail Convertible Preferred Stock - Description of Convertible Preferred Stock - Additional Information (Detail) Details 44 false false R45.htm 100460 - Disclosure - Convertible Preferred Stock - Summary of Number of Shares of Common Stock into Each Share of Convertible Preferred Stock Converted (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureConvertiblePreferredStockSummaryOfNumberOfSharesOfCommonStockIntoEachShareOfConvertiblePreferredStockConvertedDetail Convertible Preferred Stock - Summary of Number of Shares of Common Stock into Each Share of Convertible Preferred Stock Converted (Detail) Details 45 false false R46.htm 100470 - Disclosure - Stockholders' Deficit - Common Stock - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficitCommonStockAdditionalInformationDetail Stockholders' Deficit - Common Stock - Additional Information (Detail) Details 46 false false R47.htm 100480 - Disclosure - Stockholders' Deficit - Common Stock Warrants - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficitCommonStockWarrantsAdditionalInformationDetail Stockholders' Deficit - Common Stock Warrants - Additional Information (Detail) Details 47 false false R48.htm 100490 - Disclosure - Stockholders' Deficit - Summary of Shares of Common Stock Reserved for Future Issuance (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureStockholdersDeficitSummaryOfSharesOfCommonStockReservedForFutureIssuanceDetail Stockholders' Deficit - Summary of Shares of Common Stock Reserved for Future Issuance (Detail) Details 48 false false R49.htm 100500 - Disclosure - Equity Incentive Plans - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansAdditionalInformationDetail Equity Incentive Plans - Additional Information (Detail) Details 49 false false R50.htm 100510 - Disclosure - Equity Incentive Plans - Stock Options - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansStockOptionsAdditionalInformationDetail Equity Incentive Plans - Stock Options - Additional Information (Detail) Details 50 false false R51.htm 100520 - Disclosure - Equity Incentive Plans - Summary of Changes in Options Outstanding and Related Exercise Prices for Company's Common Stock Options Issued (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansSummaryOfChangesInOptionsOutstandingAndRelatedExercisePricesForCompanySCommonStockOptionsIssuedDetail Equity Incentive Plans - Summary of Changes in Options Outstanding and Related Exercise Prices for Company's Common Stock Options Issued (Detail) Details 51 false false R52.htm 100530 - Disclosure - Equity Incentive Plans - Restricted Stock Awards - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansRestrictedStockAwardsAdditionalInformationDetail Equity Incentive Plans - Restricted Stock Awards - Additional Information (Detail) Details 52 false false R53.htm 100540 - Disclosure - Equity Incentive Plans - Fair Value of Stock Options Grants, Weighted Average Assumptions (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansFairValueOfStockOptionsGrantsWeightedAverageAssumptionsDetail Equity Incentive Plans - Fair Value of Stock Options Grants, Weighted Average Assumptions (Detail) Details 53 false false R54.htm 100550 - Disclosure - Equity Incentive Plans - Schedule of Total Stock-Based Compensation Expense (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansScheduleOfTotalStockBasedCompensationExpenseDetail Equity Incentive Plans - Schedule of Total Stock-Based Compensation Expense (Detail) Details 54 false false R55.htm 100560 - Disclosure - Equity Incentive Plans - Stock-Based Compensation - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureEquityIncentivePlansStockBasedCompensationAdditionalInformationDetail Equity Incentive Plans - Stock-Based Compensation - Additional Information (Detail) Details 55 false false R56.htm 100570 - Disclosure - Related Party Transactions - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureRelatedPartyTransactionsAdditionalInformationDetail Related Party Transactions - Additional Information (Detail) Details 56 false false R57.htm 100580 - Disclosure - Income Taxes - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxesAdditionalInformationDetail Income Taxes - Additional Information (Detail) Details 57 false false R58.htm 100590 - Disclosure - Income Taxes - Reconciliation of Statutory Federal Income Tax Rate and Effective Income Tax Rate (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxesReconciliationOfStatutoryFederalIncomeTaxRateAndEffectiveIncomeTaxRateDetail Income Taxes - Reconciliation of Statutory Federal Income Tax Rate and Effective Income Tax Rate (Detail) Details 58 false false R59.htm 100600 - Disclosure - Income Taxes - Summary of Significant Components of Deferred Tax Assets and Liabilities (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureIncomeTaxesSummaryOfSignificantComponentsOfDeferredTaxAssetsAndLiabilitiesDetail Income Taxes - Summary of Significant Components of Deferred Tax Assets and Liabilities (Detail) Details 59 false false R60.htm 100610 - Disclosure - Commitments and Contingencies - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingenciesAdditionalInformationDetail Commitments and Contingencies - Additional Information (Detail) Details 60 false false R61.htm 100620 - Disclosure - Commitments and Contingencies - Information Related to Right-of-use Assets and Lease Liabilities (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingenciesInformationRelatedToRightOfUseAssetsAndLeaseLiabilitiesDetail Commitments and Contingencies - Information Related to Right-of-use Assets and Lease Liabilities (Detail) Details 61 false false R62.htm 100630 - Disclosure - Commitments and Contingencies - Schedule of Maturities of Lease Liabilities (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureCommitmentsAndContingenciesScheduleOfMaturitiesOfLeaseLiabilitiesDetail Commitments and Contingencies - Schedule of Maturities of Lease Liabilities (Detail) Details 62 false false R63.htm 100650 - Disclosure - Segments and Geographic Information - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformationAdditionalInformationDetail Segments and Geographic Information - Additional Information (Detail) Details 63 false false R64.htm 100660 - Disclosure - Segments and Geographic Information - Revenues, Expenses and Operating Income (Loss) by Market Segment (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformationRevenuesExpensesAndOperatingIncomeLossByMarketSegmentDetail Segments and Geographic Information - Revenues, Expenses and Operating Income (Loss) by Market Segment (Detail) Details 64 false false R65.htm 100670 - Disclosure - Segments and Geographic Information - Summary of Significant Revenues in Following Regions (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSegmentsAndGeographicInformationSummaryOfSignificantRevenuesInFollowingRegionsDetail Segments and Geographic Information - Summary of Significant Revenues in Following Regions (Detail) Details 65 false false R66.htm 100680 - Disclosure - Subsequent Events - Additional Information (Detail) Sheet http://www.internationalstemcell.com/20211231/taxonomy/role/DisclosureSubsequentEventsAdditionalInformationDetail Subsequent Events - Additional Information (Detail) Details 66 false false All Reports Book All Reports isco-10k_20211231.htm isco-20211231.xsd isco-20211231_cal.xml isco-20211231_def.xml isco-20211231_lab.xml isco-20211231_pre.xml isco-ex1012_10.htm isco-ex1013_12.htm isco-ex1014_9.htm isco-ex231_13.htm isco-ex311_8.htm isco-ex312_7.htm isco-ex321_6.htm isco-ex322_11.htm http://fasb.org/us-gaap/2021-01-31 http://xbrl.sec.gov/dei/2021q4 true true