X0303 4 2010-01-01 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001355537 Polymeropoulos Mihael Hristos 9605 MEDICAL CENTER DRIVE SUITE 300 ROCKVILLE MD 20850 1 1 0 0 President and CEO Restricted Stock Units 2010-01-01 4 A 0 75000 0.00 A Common Stock 75000 75000 D The Restricted Stock Units represent a contingent right to receive a share of the Issuer's common stock. The Restricted Stock Units vest in four equal annual installments beginning January 1, 2011. Vested shares will be delivered on the First Permissable Trading Day (as defined in the Restricted Stock Unit Agreement) that occurs on or after the day when the Restricted Stock Units vest. N/A /s/ Mihael H. Polymeropoulos 2010-01-05