X0306 4 2021-02-16 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0001352908 Hayden Michael R 200 - 3650 GILMORE WAY BURNABY A1 V5G 4W8 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2021-02-16 4 M 0 5144 2.68 A 112706 D Common Shares 2021-02-18 4 M 0 10288 3.67 A 61212 I By Genworks Inc. Common Shares 2021-02-18 4 M 0 30864 2.68 A 92076 I By Genworks Inc. Common Shares 114403 I By wife Stock Option (Right to Buy) 2.68 2021-02-16 4 M 0 5144 0.00 D 2022-12-31 Common Shares 5144 0 D Stock Option (Right to Buy) 3.67 2021-02-18 4 M 0 10288 0.00 D 2021-12-31 Common Shares 10288 0 I By Genworks Inc. Stock Option (Right to Buy) 2.68 2021-02-18 4 M 0 30864 0.00 D 2022-12-31 Common Shares 30864 0 I By Genworks Inc. The exercise price was converted from $2.67 CAD using the closing rate of exchange of the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. The exercise price was converted from $3.74 CAD using the closing rate of exchange of the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise. Michael Hayden is the president and principal beneficial shareholder of Genworks Inc. 1/3 of the shares subject to the Option vested on January 1, 2014 (the "Second 2013 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the Second 2013 Vesting Commencement Date over the following 2 years. 25% of the shares subject to the Option vested on the one year anniversary of January 1, 2012 (the "2012 Vesting Commencement Date") and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the 2012 Vesting Commencement Date. 25% of the shares subject to the Option vested on the one year anniversary of January 1, 2013 (the "First 2013 Vesting Commencement Date") and thereafter 1/48th of the shares subject to the Option vest on each monthly anniversary of the First 2013 Vesting Commencement Date. /s/ Cassandra Robinson, Attorney-in-fact 2021-02-18