Select Condensed Consolidated Balance Sheet Details - Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Commissions and sales milestones	$ 3,455	$ 3,963
Payroll and payroll related	2,621	3,947
Deferred revenue from Globus Transaction	3,900	0
Globus inventory obligation	2,375	0
Litigation settlements	4,400	4,400
Accrued professional fees	2,199	1,972
Royalties	1,340	1,199
Restructuring and severance accruals	1,463	505
Accrued taxes	3,849	765
Guaranteed collaboration compensation, current	1,543	0
Accrued interest	205	999
Other	3,355	3,425
Total accrued expenses	$ 30,705	$ 21,175