Organization and Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2022

Accounting Policies [Abstract]

Computation of Basic and Diluted Loss Per Share

The following table sets forth the computation of basic and diluted loss per share (in thousands, except per share data):

	Year Ended December 31,
	2022			2021			2020
Numerator:
Net loss	$	(152,149	)	$	(144,326	)	$	(78,994	)
Denominator:
Weighted average common shares outstanding		103,373			96,197			67,020
Net loss per share, basic and diluted	$	(1.47	)	$	(1.50	)	$	(1.18	)

Anti-Dilutive Securities of Common Stock Excluded from Calculation of Diluted Net Loss Per Share

The following potentially dilutive shares of common stock were excluded from the calculation of diluted net loss per share because their effect would have been anti-dilutive for the years presented (in thousands):

	Year Ended December 31,
	2022		2021		2020
Series A convertible preferred stock		—		29		29
Options to purchase common stock and employee stock purchase plan		2,991		3,416		3,951
Unvested restricted stock units		8,533		8,703		8,216
Warrants to purchase common stock		15,491		20,184		24,881
Senior convertible notes		17,246		17,246		—
		44,261		49,578		37,077