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                             July 2, 2020

       John Roberts
       Chief Executive Officer and President
       CANCER GENETICS, INC
       201 Route 17 North, 2nd Floor
       Rutherford, NJ 07070

                                                        Re: CANCER GENETICS,
INC
                                                            Registration
Statement on Form S-3
                                                            Filed June 26, 2020
                                                            File No. 333-239497

       Dear Mr. Roberts:

              We have limited our review of your registration statement to
those issues we have
       addressed in our comment. In some of our comments, we may ask you to
provide us with
       information so we may better understand your disclosure.

               Please respond to this letter by amending your registration
statement and providing
       the requested information. If you do not believe our comment applies to
your facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to the comment, we may have additional comments.

       Registration Statement on Form S-3

       General

   1.                                                   Although you filed your
Form 10-Q on June 24, 2020 in reliance on SEC Release No. 34-
                                                        88465 (March 25, 2020),
you did not satisfy the condition set forth under Section II(d) as
                                                        you did not include the
required disclosure that you were relying on SEC Release No. 34-
                                                        88465 and did not state
the reasons why you could not file such report on a timely basis.
                                                        As such, your Form 10-Q
was not filed in a timely manner, and you are not eligible at this
                                                        time to register the
offering on Form S-3. Please see General Instruction I.A.3(b) of Form
                                                        S-3. Accordingly,
please amend your registration statement onto a form for which you are
                                                        eligible, or withdraw
your registration statement and refile it as of a date that you are
                                                        eligible to use Form
S-3.
 John Roberts
CANCER GENETICS, INC
July 2, 2020
Page 2

        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Jason L. Drory at 202-551-8342 or Dorrie Yale at
202-551-8776 with any
questions.



                                                           Sincerely,
FirstName LastNameJohn Roberts
                                                           Division of
Corporation Finance
Comapany NameCANCER GENETICS, INC
                                                           Office of Life
Sciences
July 2, 2020 Page 2
cc:       Alan Wovsaniker, Esq.
FirstName LastName